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	Provedor de dados 19 (1) 69 (1) Autor Bolboaca,Sorana D (1) Hashimoto, Makoto (1) Hatanaka, Yasumaru (1) Jäntschi,Lorentz (1) Popescu,Violeta (1) 橋本, 誠 (1) Mais... Palavra-chave Structure-activity relationships (2) Bioorganic chemistry (1) Chemical biology (1) Diazirine (1) Para-substituted phenol derivatives (1) Photoaffinity labeling (1) Tetrahymena pyriformis (1) Toxicity (1) Mais... Tipo do documento Journal article (1) Ano 2008 (2) País Chile (1) Japan (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Toxicity caused by para-substituted phenols on Tetrahymena pyriformis: The structure-activity relationships 69 Jäntschi,Lorentz; Popescu,Violeta; Bolboaca,Sorana D. The toxicity of thirty para-substituted phenols on Tetrahymena pyriformis was modelled using an original methodology that uses the complex structural information of the compounds. Two models were built. The methodology allows atomic properties to be assigned to toxicity based on the selection of pairs of descriptors from the entire family, which is called Molecular Descriptors Family (MDF). One model has two independent structural descriptors and the other has four. The model with four descriptors proved to have high estimated and predictive abilities (over 97% of toxicity could be explained by structural information). The partial charge distribution by bonds (molecular topology) and space (molecular geometry) interaction proved to be related with the... Tipo: Journal article Palavras-chave: Para-substituted phenol derivatives; Structure-activity relationships; Tetrahymena pyriformis; Toxicity. Ano: 2008 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582008000300012 Recent progress in diazirine based photoaffinity labeling 19 Hashimoto, Makoto; Hatanaka, Yasumaru; 橋本, 誠. Based on the recent development of molecular biology, the investigation of biofunctional machinery at their ligand accepting interface has become one of the challenging and important subject of post-genome field. The technique of photoaffinity labeling has become increasingly appreciated as a powerful methodology for the purpose. This micro review focused synthesis of trifluoromethylphenyldiazirine, which is one of the most promising photophore, and its application to the biomolecules. Palavras-chave: Photoaffinity labeling; Chemical biology; Bioorganic chemistry; Structure-activity relationships; Diazirine. Ano: 2008 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2700 Registros recuperados: 2 Primeira ... 1 ... Última

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