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In vitro antimicrobial activity of a new series of 1,4-naphthoquinones BJMBR
Riffel,A.; Medina,L.F.; Stefani,V.; Santos,R.C.; Bizani,D.; Brandelli,A..
The antibacterial activity of a series of 1,4-naphthoquinones was demonstrated. Disk diffusion tests were carried out against several Gram-positive and Gram-negative bacteria. The compound 5-amino-8-hydroxy-1,4-naphthoquinone was the most effective, presenting inhibition zones measuring 20 mm against staphylococci, streptococci and bacilli at 50 µg/ml. Methicillin-resistant Staphylococcus aureus and several clinical isolates of this bacterium were also inhibited. Naphthazarin, 5-acetamido-8-hydroxy-1,4-naphthoquinone, and 2,3-diamino-1,4-naphthoquinone were the next most active compounds. The minimal inhibitory concentration of the active compounds was determined against S. aureus, ranging from 30 to 125 µg/ml. All compounds presented a minimal...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 5-Amino-8-hydroxy-1; 4-naphthoquinone Antimicrobial agent Staphylococcus aureus Quinone Naphthazarin 5-Acetamido-8-hydroxy-1; 4-naphthoquinone 2; 3-Diamino-1; 4-naphthoquinone.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700008
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Molluscicidal activity of 2-hydroxy-[1,4]naphthoquinone and derivatives Anais da ABC (AABC)
Camara,Celso A.; Silva,Tania M.S.; da-Silva,Thiago G.; Martins,Rodrigo M.; Barbosa,Ticiano P.; Pinto,Angelo C.; Vargas,Maria D..
The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 µg/mL set for potential molluscicidal activity by the World Health Organization. As a general rule derivatives with non-polar substituents presented the highest molluscicidal activities. These substances showed significant toxicity in A. salina lethality bioassay.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Biomphalaria glabrata Artemia salina toxicity quinones schistosomiasis molluscicidal activity lawsone 1; 4-naphthoquinone.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000200011
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2-Bromo-1,4-naphthoquinone: a potentially improved substitute of menadione in Apatone™ therapy BJMBR
Graciani,F.S.; Ximenes,V.F..
Apatone™, a combination of menadione (2-methyl-1,4-naphthoquinone, VK3) and ascorbic acid (vitamin C, VC) is a new strategy for cancer treatment. Part of its effect on tumor cells is related to the cellular pro-oxidative imbalance provoked by the generation of hydrogen peroxide (H2O2) through naphthoquinone redox cycling. In this study, we attempted to find new naphthoquinone derivatives that would increase the efficiency of H2O2 production, thereby potentially increasing its efficacy for cancer treatment. The presence of an electron-withdrawing group in the naphthoquinone moiety had a direct effect on the efficiency of H2O2 production. The compound 2-bromo-1,4-naphthoquinone (BrQ), in which the bromine atom substituted the methyl group in VK3, was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer Apatone™ Ascorbic acid Hydrogen peroxide 2-Bromo-1; 4-naphthoquinone.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000800003
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