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	Provedor de dados BJPS (1) Autor Kandhasami,Uma Devi Subbaih (1) Ramasamy,Thiruganesh (1) Ruttala,Himabindhu (1) Shanmugam,Suresh (1) Palavra-chave Aceclofenac/release colon targeted (1) Colon targeting (1) Drugs/release colon targeted (1) Eudragit coating (1) In vitro dissolution (1) Targeted delivery (1) Xanthan gum (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2011 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Formulation and evaluation of xanthan gum based aceclofenac tablets for colon targeted drug delivery BJPS Ramasamy,Thiruganesh; Kandhasami,Uma Devi Subbaih; Ruttala,Himabindhu; Shanmugam,Suresh. The objective of the present study is to develop a colon targeted drug delivery systems for Aceclofenac using xanthan gum as a carrier. In this study, multilayer coated system that is resistant to gastric and small intestinal conditions but can be easily degraded by colonic bacterial enzymes was designed to achieve effective colon delivery of Aceclofenac. The xanthan gum, the drug and the physical mixture were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). All the formulations were evaluated for hardness, drug content uniformity and other physical properties. Release aspects of Aceclofenac in simulated gastrointestinal fluid and colonic fluid with enzymes were investigated. From these results,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drugs/release colon targeted; Aceclofenac/release colon targeted; Xanthan gum; Colon targeting; Eudragit coating; In vitro dissolution; Targeted delivery. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200011 Registros recuperados: 1 Primeira ... 1 ... Última

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