Consulta: subjectFacets:"Ancestry informative markers"
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Data/hora: 27/07/2024 02:41:36

Prevalence of IFNL3 gene polymorphism among blood donors and its relation to genomic profile of ancestry in Brazil
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Rizzo,Silvia Renata Cornelio Parolin; Gazito,Diana; Pott-Junior,Henrique; Latini,Flavia Roche Moreira; Castelo,Adauto.
ABSTRACT The recent development of interferon-free regimens based on direct-acting antivirals for the treatment of chronic hepatitis C virus infection has benefited many but not all patients. Some patients still experience treatment failure, possibly attributed to unknown host and viral factors, such as IFNL3 gene polymorphism. The present study assessed the prevalence of rs12979860-CC, rs12979860-CT, and rs12979860-TT genotypes of the IFNL3 gene, and its relationship with ancestry informative markers in 949 adult Brazilian healthy blood donors. Race was analyzed using ancestry informative markers as a surrogate for ancestry. IFNL3 gene was genotyped using the ABI TaqMan single nucleotide polymorphisms genotyping assays. The overall frequency of...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Ancestry informative markers; Chronic hepatitis C virus infection; Direct-acting antivirals; Single nucleotide polymorphisms.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600619