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Registros recuperados: 5
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Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans BJM
Chiuchetta,Simone Jurema Ruggeri; Castro-Prado,Marialba Avezum Alves de.
Doxorubicin and etoposide are intercalating agents that inhibit the action of the enzyme topoisomerase II. Both drugs present therapeutic activity in numerous human neoplasms In the present work the recombinagenic potential of these drugs was evaluated by ascomycete Aspergillus nidulans. Their effects on the asexual cycle of A. nidulans was also appraised. Two heterozygous diploid strains of A. nidulans, a wild (uvsH+//uvsH+) and a defective to the DNA repair (uvsH//uvsH) were used. The drugs' recombinagenic potential was evaluated by their capacity to induce homozygosis of recessive genes from heterozygous cells. Both drugs have a recombinagenic effect on diploid cells of A. nidulans. Doxorubicin and etoposide are potentially capable to induce secondary...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antineoplastic agents; Mitotic crossing-over; Secondary malignances.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300014
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Genotoxicity of the cyclo-oxygenase-inhibitor sulindac sulfide in the filamentous fungus Aspergillus nidulans BJM
Franco,Claudinéia Conationi da Silva; Miyamoto,Claudia Tiemi; Sant'Anna,Juliane Rocha de; Castro-Prado,Marialba Avezum Alves de.
Sulindac sulfide is a non-steroidal anti-inflammatory drug (NSAID) with chemopreventive effect on human cancer cells. Due to the involvement of the somatic recombination in the carcinogenic process, sulindac sulfide's recombinogenic potential was evaluated by the Homozygotization Index (HI) in the filamentous fungus Aspergillus nidulans. The drug's recombinogenic potential was evaluated by its capacity to induce homozygosis of recessive genes from heterozygous diploid cells. Sulindac sulfide at 175 and 350 µM concentrations induced mitotic recombination in A. nidulans diploid cells, with HI values for genetic markers higher than 2.0, and significantly different from control HI values. The recombinogenic effect of NSAID was related to the induction of DNA...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antineoplastic agents; Mitotic crossing-over; Secondary malignances.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000300009
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SCORPION VENOM: NEW PROMISE IN THE TREATMENT OF CANCER Acta biol.Colomb.
GÓMEZ RAVE,Lyz Jenny; MUÑOZ BRAVO,Adriana Ximena; SIERRA CASTRILLO,Jhoalmis; ROMÁN MARÍN,Laura Melisa; CORREDOR PEREIRA,Carlos.
ABSTRACT Cancer is a public health problem due to its high worldwide morbimortality. Current treatment protocols do not guarantee complete remission, which has prompted to search for new and more effective antitumoral compounds. Several substances exhibiting cytostatic and cytotoxic effects over cancer cells might contribute to the treatment of this pathology. Some studies indicate the presence of such substances in scorpion venom. In this review, we report characteristics of the principal scorpion venom components found in recent literature and their potential activity against tumor cells. There are different toxin groups present in the venom, and it seems that their mode of actions involves ionic channel blocking, disruption of the cell membrane...
Tipo: Journal article Palavras-chave: Anti-infective agents; Antineoplastic agents; Arachnida; Molecular biology; Peptides.
Ano: 2019 URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2019000200213
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The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB Anais da ABC (AABC)
DELOU,JOÃO M.A.; BIASOLI,DEBORAH; BORGES,HELENA L..
ABSTRACT Physiological processes, as autophagy, proliferation and apoptosis are affected during carcinogenesis. Restoring cellular sensitivity to apoptotic stimuli, such as the antineoplastic cocktails, has been explored as a strategy to eliminate cancer cells. Autophagy, a physiological process of recycling organelles and macromolecules can be deviated from homeostasis to support cancer cells survival, proliferation, escape from apoptosis, and therapy resistance. The relationship between autophagy and apoptosis is complex and many stimuli can induce both processes. Most chemotherapeutic agents induce autophagy and it is not clear whether and how this chemotherapy-induced autophagy might contribute to resistance to apoptosis. Here, we review current...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Retinoblastoma; Neoplasm; Autophagy; Cell death; Antineoplastic agents.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602257
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Thermodynamics of molecular recognitions between antineoplastic drug taxol and phosphatidylcholine BABT
Süleymanoglu,Erhan.
The aim of this study was to study the basic features of Taxol recognition with phospholipids by applying the thermodynamic and spectroscopic measurements. The obtained information could be used further for deductions on its precise cellular and pharmacological mechanisms of action, on improvements of its solubility properties by phospholipids, as well as for designing the novel lipidic carriers for drug delivery.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antineoplastic agents; Chemotherapy; Taxol; Phoshatidylcholine; Taxol-membrane interactions; Membrane fluidity.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600011
Registros recuperados: 5
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