Data/hora: 27/07/2024 01:53:06

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Association between vitamin B12 level and anti-parietal cells and anti-intrinsic factor antibodies among adult Jordanian patients with Helicobacter pylori infection	
Autores: 	Ayesh,Mahmoud H.; Jadalah,Khaled; Awadi,Eiman Al; Alawneh,Khaldoon; Khassawneh,Basheer.	
Data: 	2013-12-01	
Ano: 	2013	
Palavras-chave: 	Vitamin B12; Anti-parietal cell antibodies; Anti-intrinsic factor antibodies; H. pyloriby.	
Resumo: 	OBJECTIVE: Evaluate the association of Helicobacter pylori infection with anti-parietal cell antibodies (APCA) and anti-intrinsic factor antibodies (AIFA) and their impact on vitamin B12 serum level. PATIENTS AND METHODS: One hundred patients (M/F: 43/57; age 46.5 ± 17.5 years) who underwent upper gastrointestinal endoscopy at King Abdullah University Hospital, Irbid, Jordan were enrolled in the study. The patients were grouped as H. pylori-infected (n = 81) or H. pylori negative (n = 19) by histopathological examination. Fasting serum vitamin B12 levels, antiparietal cell antibodies and anti-intrinsic factor antibodies for patients and controls were determined. RESULTS: Anti-parietal cell antibodies and anti-intrinsic factor antibodies were positive in 9.9% and 18.5% of H. pylori-positive patients respectively. None of the H. pylori negative subjects had anti-parietal cell antibodies or anti-intrinsic factor antibodies. Serum vitamin B12 level was lower in the H. pylori-infected patients (275 ± 70.4 pg/mL) than in controls (322.9 ± 60.7 pg/mL; p 0.05). H. pylori was positive in 94% of the low-vitamin B12 group compared with 64.6% of the normal-vitamin B12 group (p 0.5). CONCLUSION: Patients with H. pylori infection are more likely to have anti-parietal cell antibodies and anti-intrinsic factor antibodies. There was an association between H. pylori infection and lower vitamin B12 levels. H. pylori infection might be a significant factor in the pathogenesis of autoimmune gastritis.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600001	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2013.01.009	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.17 n.6 2013	
Fonte: 	info:eu-repo/semantics/openAccess