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| Xu,Yu‑Dong; Wang,Yu; Yin,Lei‑Miao; Peng,Ling‑Ling; Park,Gyoung‑Hee; Yang,Yong‑Qing. |
| Abstract Background Airway remodeling is a key feature of asthma, characterized by increased proliferation of airway smooth muscle cells (ASMCs). S100A8 is a calcium‑binding protein with a potential to regulate cell proliferation. Here, the effect of exogenous S100A8 protein on the proliferation of ASMCs induced by platelet‑derived growth factor (PDGF) and the underlying molecular mechanism was investigated. Methods Rat ASMCs were cultured with or without a neutralizing antibody to the receptor for advanced glycation end‑products (RAGE), a potential receptor for S100A8 protein. Purified recombinant rat S100A8 protein was then added into the cultured cells, and the proliferation of ASMCs induced by PDGF was detected by... |
| Tipo: Journal article |
Palavras-chave: S100A8 Airway smooth muscle cells Cell proliferation The receptor for advanced glycation end‑ Products Platelet‑ Derived growth factor. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100216 |
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