|Otero,Luize; Souza,Daiane Correa de; Tavares,Rita de Cássia; Gomes,Bernadete Evangelho; Padilha,Telma França; Bouzas,Luiz Fernando; Fernandez,Teresa de Souza; Abdelhay,Eliana.|
|Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.|
||Palavras-chave: Monosomy 7; Donor cell leukemia; Bone marrow transplantation; Severe aplastic anemia.