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	Provedor de dados 60 (1) Autor Bairros,André Valle de (1) Cordeiro,Everson Willian Fialho (1) Malesuik,Marcelo Donadel (1) Paim,Clésio Soldateli (1) Paula,Fávero Reisdorfer (1) Pereira,Danillo Baptista (1) Silva,Fabiana Ernestina Barcellos da (1) Mais... Palavra-chave Fluoroquinolones/evaluation (1) Forced degradation studies (1) Molecular modeling (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Evaluation of the influence of fluoroquinolone chemical structure on stability: forced degradation and in silico studies 60 Bairros,André Valle de; Pereira,Danillo Baptista; Cordeiro,Everson Willian Fialho; Paim,Clésio Soldateli; Silva,Fabiana Ernestina Barcellos da; Malesuik,Marcelo Donadel; Paula,Fávero Reisdorfer. ABSTRACT Fluoroquinolones are a known antibacterial class commonly used around the world. These compounds present relative stability and they may show some adverse effects according their distinct chemical structures. The chemical hydrolysis of five fluoroquinolones was studied using alkaline and photolytic degradation aiming to observe the differences in molecular reactivity. DFT/B3LYP-6.31G* was used to assist with understanding the chemical structure degradation. Gemifloxacin underwent degradation in alkaline medium. Gemifloxacin and danofloxacin showed more degradation perceptual indices in comparison with ciprofloxacin, enrofloxacin and norfloxacin in photolytic conditions. Some structural features were observed which may influence degradation, such... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fluoroquinolones/evaluation; Forced degradation studies; Molecular modeling. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100604 Registros recuperados: 1 Primeira ... 1 ... Última

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