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Autoimmunity and molecular mimicry in tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy BJMBR
García-Vallejo,F.; Domínguez,M.C.; Tamayo,O..
Viruses share antigenic sites with normal host cell components, a phenomenon known as molecular mimicry. It has long been suggested that viral infections might trigger an autoimmune response by several mechanisms including molecular mimicry. More than 600 antiviral monoclonal antibodies generated against 11 different viruses have been reported to react with 3.5% of cells specific for uninfected mouse organs. The main pathological feature of tropical spastic paraparesis/human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (TSP/HAM) is a chronic inflammation of the spinal cord characterized by perivascular cuffing of mononuclear cells accompanied by parenchymal lymphocytic infiltration. We detected the presence of autoantibodies against a 98- to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HTLV-I; TSP/HAM; Retrovirus; Molecular mimicry.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000200013
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Human T-cell lymphotropic virus type I (HTLV-I) proviral DNA viral load among asymptomatic patients and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis BJMBR
Montanheiro,P.A.; Penalva de Oliveira,A.C.; Posada-Vergara,M.P.; Milagres,A.C.; Tauil,C.; Marchiori,P.E.; Duarte,A.J.S.; Casseb,J..
To evaluate the human T-cell lymphotropic virus type I (HTLV-I) proviral DNA load among asymptomatic HTLV-I-infected carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), real time PCR using TaqMan probes for the pol gene was performed in two million peripheral blood mononuclear cells (PBMC). The albumin gene was the internal genomic control and MT2 cells were used as positive control. The results are reported as copies/10,000 PBMC, and the detection limit was 10 copies. A total of 89 subjects (44 HAM/TSP and 45 healthy HTLV-I-infected carriers) followed up at the Institute of Infectious Diseases "Emilio Ribas" and in the Neurology Division of Hospital of Clínicas were studied. The asymptomatic HTLV-I-infected...
Tipo: Info:eu-repo/semantics/other Palavras-chave: HTLV-I; HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP); HTLV-I DNA viral load.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001100011
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Association of HTLV-I with Arnold Chiari syndrome and syringomyelia BJID
Viana,Graça Maria de Castro; Diniz Neto,João Arnaud; Furtado,Igor de Sousa; Binda Júnior,José Roberto; Tanaka,Bárbara Neiva; Nascimento,Maria do Desterro Soares Brandão.
HTLV-I is associated with a broad spectrum of manifestations, including tropical spastic paraparesis and adult T-cell leukemia/lymphoma. Arnold Chiari syndrome is a condition characterized by herniation of the cerebellar tonsils through the foramen magnum. This condition should be suspected in all patients with headache and impaired motor coordination. Syringomyelia is a developmental anomaly that leads to the formation of an intramedullary cavity. Its clinical presentation is classically characterized by syringomyelic dissociation of sensation, with suspended distribution in the proximal portion of the trunk and upper limbs and preservation in other regions. We report here a case of association of the three diseases, which is rare in clinical practice,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HTLV-I; Arnold Chiari syndrome; Syringomyelia.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600018
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Possible etiologies for tropical spastic paraparesis and human T lymphotropic virus I-associated myelopathy BJMBR
Zaninovic',V..
The epidemiology of tropical spastic paraparesis/human T lymphotropic virus I (HTLV-I)-associated myelopathy (TSP/HAM) is frequently inconsistent and suggests environmental factors in the etiology of these syndromes. The neuropathology corresponds to a toxometabolic or autoimmune process and possibly not to a viral disease. Some logical hypotheses about the etiology and physiopathology of TSP and HAM are proposed. Glutamate-mediated excitotoxicity, central distal axonopathies, cassava, lathyrism and cycad toxicity may explain most cases of TSP. The damage caused to astrocytes and to the blood-brain barrier by HTLV-I plus xenobiotics may explain most cases of HAM. Analysis of the HTLV-I/xenobiotic ratio clarifies most of the paradoxical epidemiology of TSP...
Tipo: Info:eu-repo/semantics/article Palavras-chave: TSP/HAM; Paradoxical epidemiology; Toxic and toxoviral etiologies; HTLV-I; Glutamate; Astrocytes; Cycads; Cassava.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100001
Registros recuperados: 4
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