Data/hora: 27/07/2024 02:43:11

Provedor de dados: 	Institutional Archive of Ifreme (ArchiMer)	
País: 	France	
Título: 	Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis	
Autores: 	El-demerdash, Amr; Moriou, Celine; Toullec, Jordan; Besson, Marc; Soulet, Stephanie; Schmitt, Nelly; Petek, Sylvain; Lecchini, David; Debitus, Cecile; Al-mourabit, Ali.	
Data: 	2018-05	
Ano: 	2018	
Palavras-chave: 	Brominated tyrosine alkaloids; Suberea ianthelliformis; Cytotoxicity; Acetylcholinesterase inhibition.	
Resumo: 	Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	https://archimer.ifremer.fr/doc/00439/55076/56506.pdf

https://archimer.ifremer.fr/doc/00439/55076/56507.pdf

DOI:10.3390/md16050146

https://archimer.ifremer.fr/doc/00439/55076/	
Editor: 	Mdpi	
Relação: 	info:eu-repo/grantAgreement/EC/FP7/634674/EU//TASCMAR	
Formato: 	application/pdf	
Fonte: 	Marine Drugs (1660-3397) (Mdpi), 2018-05 , Vol. 16 , N. 5 , P. 146 (16p.)	
Fonte: 	2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

info:eu-repo/semantics/openAccess

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