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Lipid rafts: cell surface platforms for T cell signaling Biol. Res.
MAGEE,TONY; PIRINEN,NIINA; ADLER,JEREMY; PAGAKIS,STAMATIS N; PARMRYD,INGELA.
The Src family tyrosine kinase Lck is essential for T cell development and T cell receptor (TCR)* signaling. Lck is post-translationally fatty acylated at its N-terminus conferring membrane targeting and concentration in plasma membrane lipid rafts, which are lipid-based organisational platforms. Confocal fluorescence microscopy shows that Lck colocalises in rafts with GPI-linked proteins, the adaptor protein LAT and Ras, but not with non-raft membrane proteins including the protein tyrosine phosphatase CD45. The TCR also associates with lipid rafts and its cross-linking causes coaggregation of raft-associated proteins including Lck, but not of CD45. Cross-linking of either the TCR or rafts strongly induces specific tyrosine phosphorylation of the TCR in...
Tipo: Journal article Palavras-chave: Lipid rafts; Lck; Tyrosine kinase; T cell; Signalling; Phosphatase.
Ano: 2002 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200003
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