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| CUDDON,PAUL; BOOTMAN,MARTIN D; RICHARDS,GILLIAN R; SMITH,ALISON J; SIMPSON,PETER B; RODERICK,H LLEWELYN. |
| Neurons are a diverse cell type exhibiting hugely different morphologies and neurotransmitter specifications. Their distinctive phenotypes are established during differentiation from pluripotent precursor cells. The signalling pathways that specify the lineage down which neuronal precursor cells differentiate remain to be fully elucidated. Among the many signáis that impinge on the differentiation of neuronal cells, cytosolic calcium (Ca2+) has an important role. However, little is known about the nature of the Ca2+ signáis involved in fate choice in neuronal precursor cells, or their sources. In this study, we show that activation of either muscarinic or platelet-derived growth factor (PDGF) receptors induces a biphasic increase in cytosolic Ca2+ that... |
| Tipo: Journal article |
Palavras-chave: Ca2+; PDGF; Methacholine; TRPC6; SOCE; Human neurosphere-derived cells. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200008 |
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| Kasahara,D.I.; Perini,A.; Lopes,F.D.T.Q.S.; Arantes-Costa,F.M.; Martins,M.A.; Nunes,M.P.T.. |
| Beta-2-agonists have been widely used by asthmatic subjects to relieve their obstructive symptoms. However, there are reports that continuous use could lead to loss of bronchial protection and exacerbation of asthma symptoms. We evaluated the effect of two regimens of salbutamol administration (twice and five times a week) in a model of chronic airway inflammation in male Hartley guinea pigs (protocol starting weight: 286 ± 30 g) induced by repeated exposures to aerosols of ovalbumin (OVA). After sensitization, guinea pigs were exposed to aerosols of 0.1 mg/ml salbutamol solution twice a week (OVA + S2x, N = 7) or five times a week (OVA + S5x, N = 8). We studied allergen-specific (OVA inhalation time) and -nonspecific (response to methacholine) respiratory... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Salbutamol; Methacholine; Experimental asthma; Beta-agonist; Pulmonary responsiveness. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500009 |
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| Tlili,Mounira; Rouatbi,Sonia; Gandia,Fedoua; Hallegue,Dorsaf; Sriha,Badreddine; Yacoubi,Mohamed Taher; Krichah,Raja; Sakly,Mohsen; Rhouma,Khémais Ben; Vaudry,David; Wurtz,Olivier; Tebourbi,Olfa. |
| The aim of this study was to investigate both functionally and structurally bronchodilator effects of Pituitary adenylate cyclase activating peptide (PACAP38) and acetyl-[Ala15, Ala20] PACAP38-polyamide, a potent PACAP38 analog, in rats challenged by methacholine (MeCh). Male Wistar rats were divided randomly into five groups. Groups 1 and 2 inhaled respectively aerosols of saline or increasing doses of MeCh (0.5, 1, 2.12, 4.25, 8.5, 17, 34 and 68mg/L). The other groups received terbutaline (Terb) (250 µg/rat) (10-6 M), PACAP38 (50 µg/rat) (0.1 mM) or PACAP38 analog (50 µg/rat) associated to MeCh from the dose of 4.25 mg/L. Total lung resistances (RL) were recorded before and 2 min after MeCh administration by pneumomultitest equipment. MeCh administration... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pituitary adenylate cyclase activating peptide/effects/inflammatory lung diseases; Pituitary adenylate cyclase/analogs/effects in inflammatory lung diseases; Methacholine; Bronchodilators/effects; Inflammatory lung diseases/treatment. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300681 |
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