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A novel hot-plate test sensitive to hyperalgesic stimuli and non-opioid analgesics BJMBR
Lavich,T.R.; Cordeiro,R.S.B.; Silva,P.M.R.; Martins,M.A..
It is widely accepted that the classical constant-temperature hot-plate test is insensitive to cyclooxygenase inhibitors. In the current study, we developed a variant of the hot-plate test procedure (modified hot-plate (MHP) test) to measure inflammatory nociception in freely moving rats and mice. Following left and right hind paw stimulation with a phlogogen and vehicle, respectively, the animals were placed individually on a hot-plate surface at 51ºC and the withdrawal latency for each paw was determined simultaneously in measurements performed at 15, 60, 180, and 360 min post-challenge. Plantar stimulation of rats (250 and 500 µg/paw) and mice (125-500 µg/paw) with carrageenan led to a rapid hyperalgesic response of the ipsilateral paw that reached a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hyperalgesia; Hargreaves' test; Modified hot-plate test; Carrageenan; Prostaglandin E2; Indomethacin.
Ano: 2005 URL:
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