Data/hora: 26/07/2024 22:14:57

Provedor de dados: 	Genetics and Molecular Biology	
País: 	Brazil	
Título: 	CTLA4 CT60 gene polymorphism is not associated with differential susceptibility to pemphigus foliaceus	
Autores: 	Pincerati,Márcia Regina; Dalla-Costa,Ricardo; Petzl-Erler,Maria Luiza.	
Data: 	2010-01-01	
Ano: 	2010	
Palavras-chave: 	CTLA4; CT60 polymorphism; Pemphigus; Fogo selvagem; Autoimmunity.	
Resumo: 	Pemphigus foliaceus is an organ-specific autoimmune disease characterized by autoantibodies against the extracellular region of desmoglein 1, a protein that mediates intercellular adhesion in desmosomes. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a key negative regulator of the T cell immune response, playing an important role in T cell homeostasis and maintenance of peripheral tolerance. Polymorphisms in the CTLA4 gene have been associated with autoimmune diseases and the functional CT60 single nucleotide polymorphism (rs3087243, also named 6230G &gt; A) has been proposed to be a casual variant in several of these diseases. The aim of this study was to ascertain whether this polymorphism is associated with inter-individual variation in susceptibility to pemphigus foliaceus. The population sample in this case-control association study comprised 248 patient and 367 controls. We did not found a significant association of pemphigus foliaceus with the CT60 variants. We conclude that the CTLA4 CT60 polymorphism is not an important factor for pemphigus foliaceus pathogenesis in the population analyzed.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300008	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/S1415-47572010005000073	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.33 n.3 2010	
Fonte: 	info:eu-repo/semantics/openAccess