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Oral single dose of allopurinol in thoroughbred foals born from mares with placentitis 65
Araujo,Luciana Oliveira de; Nogueira,Carlos Eduardo Wayne; Pazinato,Fernanda Maria; Frey Junior,Friedrich; Paixão,Silvano Costa; Souza,Letícia da Silva; Curcio,Bruna da Rosa.
ABSTRACT: The aim of this study was to evaluate the effects of Allopurinol in foals born from mares with placentitis. Twenty foals were assigned into two groups: Healthy foals (n=10), born from healthy mares and Placentitis foals (n=10), born from mares with placentitis. Five foals from each group were randomly assigned to a treatment or control group. Treatment groups received Allopurinol (40mg kg-1 orally six hours after birth). Blood samples were collected for estimation of hematological variables and serum concentration of calcium, chloride, creatinine, phosphorus, glucose, lactate and magnesium. Placentitis foals presented leukopenia and neutropenia when compared with Healthy foals, at birth. The white blood cell (WBC) count was lower in the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Neonatology; Antioxidant; Therapeutic; Biochemical; Hematology..
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000601119
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Use of unlicensed and off-label drugs in neonates in a Brazilian university hospital 60
Gonçalves,Adriana Cristina de Souza; Reis,Adriano Max Moreira; Marçal,Ana Carolina Gusmão; Bouzada,Maria Cândida Ferrarez.
ABSTRACT This study was designed to investigate the use of off-label and unlicensed drugs in a Neonatal Care Unit (NCU) and to compare the frequency of use of off-label drugs according to the drug regulatory agencies in Brazil (Agência Nacional de Vigilância Sanitária-ANVISA) and the United States Food and Drug Administration (FDA). A prospective observational study was carried out in the NCU. Prescriptions were classified as off-label and unlicensed using both ANVISA and FDA criteria. A total of 157 newborns and 1187 prescriptions were analyzed. The most prescribed drug was fentanyl (9.3%), followed by multivitamin (8.4%) and gentamicin (7.9%). According to ANVISA criteria, there were 665 (56.0%) off-label prescriptions and 86 (7.2%) unlicensed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drugs/use/University Hospital/Brazil; Drug/use/off-label/unlicensed; Drug therapy; Neonatology; University Hospital/Brazil..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300622
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Influence of dexamethasone and surfactant in the vitality and lung function of preterm lambs born by cesarean section 45
Bovino,F.; Denadai,D.S.; Ávila,L.G.; Deschk,M.; Santos,P.S.P.; Feitosa,F.L.F.; Peiró,J.R.; Mendes,L.C.N..
ABSTRACT The aim of this study was to assess the vitality and lung function of preterm lambs. Twenty seven preterm lambs were divided in four groups. Group I (n=6) preterm lambs/ control; group II (n=9) lambs born to mothers that were treated with dexamethasone antepartum; group III (n=6) lambs treated with surfactant; and group IV (n=6) lambs treated with surfactant and born to mothers that were treated with dexamethasone antepartum. The APGAR score was performed after birth (T0) and 15 minutes later (T1/4) to assess vitality. The vital signs, blood gas analysis, spirometry and capnometry were assessed immediately after birth and continued until 48 hours. Chest radiographs were performed at T0, T24 and T48. Significant rectal temperature interactions...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lambs; Neonatology; Vitality; Vital parameters.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000100044
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