Data/hora: 27/07/2024 02:50:12

Provedor de dados: 	Institutional Archive of Ifreme (ArchiMer)	
País: 	France	
Título: 	Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells	
Autores: 	Hughes, Kristelle; Ho, Raimana; Greff, Stéphane; Filaire, Edith; Ranouille, Edwige; Chazaud, Claire; Herbette, Gaëtan; Butaud, Jean-françois; Berthon, Jean-yves; Raharivelomanana, Phila.	
Data: 	2020-10	
Ano: 	2020	
Palavras-chave: 	Polynesian plants; Ethnobotany; Cosmetopoeia; Dermal papilla; Hair growth; Wnt.	
Resumo: 	Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts significantly increased proliferation of dermal papilla cells. Furthermore, LC-MS/MS analysis revealed a diversity of molecules, flavonoids, iridoids and organic acids, some known for hair-inducing properties. Finally, specific extracts and fractions of all three plants either upregulated CCND1, LEF1 and PPARD involved in stimulating hair follicle proliferation and/or lowered the gene expression levels of hair growth inhibiting factors, DKK1 and TGFB1. Our findings suggest that extracts from B. pilosa, C. inophyllum and F. berteroana are interesting candidates to stimulate hair growth	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	https://archimer.ifremer.fr/doc/00652/76409/77453.pdf

https://archimer.ifremer.fr/doc/00652/76409/77454.zip

DOI:10.3390/molecules25194360

https://archimer.ifremer.fr/doc/00652/76409/	
Editor: 	MDPI AG	
Formato: 	application/pdf	
Fonte: 	Molecules (1420-3049) (MDPI AG), 2020-10 , Vol. 25 , N. 19 , P. 4360 (19p.)	
Fonte: 	info:eu-repo/semantics/openAccess

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