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| Karaboduk,Hatice; Uzunhisarcikli,Meltem; Kalender,Yusuf. |
| This study was designed to investigate the protective effects of sodium selenite and/or vitamin E against mercuric chloride-induced cardiotoxicity. Male Wistar rats (n=48, 310±10 g) were administered mercuric chloride (1.0 mg/kg bw), sodium selenite (0.25 mg/kg bw), vitamin E (100 mg/kg bw), sodium selenite plus mercuric chloride, vitamin E plus mercuric chloride and sodium selenite plus vitamin E plus mercuric chloride daily via gavage for four weeks. Malondialdehyde (MDA) level, antioxidant enzyme activities [total superoxide dismutase (SOD), catalase (CAT), total glutathione peroxidase (GPx) and total glutathione-S-transferase (GST)], and histopathological changes in the heart tissue were evaluated. Results showed that mercuric chloride exposure... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mercuric chloride; Sodium selenite; Vitamin E; Cardiotoxicity; Oxidative Stress. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000200229 |
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| Lorençoni,Roselene Modolo Regueiro; Pelai,Elisa Bizetti; Godoy,Moacir Fernandes; dos Santos,Alice Cristina Antonio; Miyoshi,Lívia Hissae; de Oliveira,Rebeca Nicolás Paronetto; Padovani,Carlos Roberto; Fregonesi,Cristina Elena Prado Teles; Camargo Filho,José Carlos Silva. |
| Physical effort stimulates an increase in oxygen consumption in tissues, generating toxic chemical species derived from oxygen (ROS), which are considered the initiators of the lipid peroxidation process (LPO), the major mechanism of cellular injury. As the essential mechanism for maintaining the electrolyte balance depends on an effective kidney function, oxidative stress in this organ can be a key factor in the development and persistence of hypertension. This study aimed to determine the kidney changes induced by a combination of fluid restriction and exercise in rats. The study consisted of 24 male Wistar rats of 90 days of age, divided into four groups, two of which were submitted to water restriction and exercise on a treadmill.Twenty-four hours... |
| Tipo: Journal article |
Palavras-chave: Morphology; Oxidative Stress; Kidney. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200039 |
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