Consulta: subjectFacets:"Parawixia bistriata"
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Data/hora: 27/07/2024 02:12:10

Neuroprotective properties of RT10, a fraction isolated from Parawixia bistriata spider venom, against excitotoxicity injury in neuron-glia cultures
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Primini,Eduardo Octaviano; Liberato,José Luiz; Fontana,Andreia Cristina Karklin; Santos,Wagner Ferreira dos.
Abstract  Background: L-Glutamate (L-Glu), the major excitatory neurotransmitter in the mammalian Central Nervous System (CNS), is essential to cognitive functions. However, when L-Glu is accumulated in large concentrations at the synaptic cleft, it can induce excitotoxicity that results in secondary damage implicated in many neurological disorders. Current therapies for the treatment of neurological disorders are ineffective and have side effects associated with their use; therefore, there is a need to develop novel treatments. In this regard, previous studies have shown that neuroactive compounds obtained from the venom of the spider Parawixia bistriata have neuroprotective effects in vitro and in vivo. In this sense, this work aimed to evaluate...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: L-Glutamate; Excitotoxicity; Neuroprotection; Parawixia bistriata; RT10.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100311