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Detection of griseofulvin in a marine strain of Penicillium waksmanii by ion trap mass spectrometry ArchiMer
Petit, Karina; Mondeguer, Florence; Roquebert, M; Biard, J; Pouchus, Y.
A marine strain of Penicillium waksmanii Zaleski was isolated from a sample of seawater from shellfish-farming area in the Loire estuary (France). The in vitro marine culture showed an important antifungal activity. Bioassay-guided fractionation was used to purify the crude extract. Dereplication by electrospray-ion trap/mass spectrometry (ESI-IT/MS) afforded the identification of the antifungal compound, after a semi-purification consisting of two stages. A comparison of the ionic composition between the active and the non-active fractions allowed the detection of a monocharged ion at m/z 353 containing a chlorine atom, which could be attributed to the antifungal griseofulvin [C17H17ClO6+H](+). Multi-stage fragmentation (MSn) confirmed the identity of the...
Tipo: Text Palavras-chave: Mass spectrometry ESI IT/MS; Griseofulvin; Antifungal; Marine fungi; Penicillium waksmanii.
Ano: 2004 URL: http://archimer.ifremer.fr/doc/2004/publication-673.pdf
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