Consulta: subjectFacets:"Peptic ulcer"
Registros recuperados: 7
Data/hora: 26/07/2024 22:45:48

Antimicrobial and anti-inflammatory activities of Apis mellifera honey on the Helicobacter pylori infection of Wistar rats gastric mucosa
Provedor de dados: Ciência e Tecnologia de Alimentos
Autores: AMARAL,Thiago Yamamoto; PADILHA,Igor Gomes; PRESÍDIO,Gustavo Alvares; SILVEIRA,Edmo Arruda Aguiar Sobreira da; DUARTE,Alysson Wagner Fernandes; BARBOSA,Ana Paula Fernandes; BEZERRA,Antônio Fernando de Souza; LÓPEZ,Ana Maria Queijeiro.
Abstract Considering that Helicobacter pylori, a bacterium able to colonize the upper gastrointestinal tract and cause mucosal injury, not always can be effectively eradicated by the traditional approaches, there is an interest in alternative therapies until a vaccine be available. Honey is a food supplement with high carbohydrate content and antioxidant activity, as well as broad antimicrobial spectrum. After analyzing the physicochemical and in vitro antimicrobial properties of an Apis mellifera honey from the Atlantic forest of Alagoas / Brazil, the purpose of the present work was evaluate its in vivo effects against Helicobacter pylori in the gastric mucosa of Wistar rats. First, it was verified the success of inoculation/infection of the pathogen in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gastritis; Peptic ulcer; Antioxidant; Anti-inflammatories; Antibiotic.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612017000500034

Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment
Provedor de dados: Brazilian Archives of Biology and Technology
Autores: Patel,Dhaval J; Patel,Jayvadan K.
The present study was performed to design and evaluate the famotidine loaded mucoadhesive nanosuspension for aspirin induced ulcer. A 3-factor, 3-level Box-Behnken design was applied to study the effects of amount of the beads (X1), PVPK-30(X2) and Tween-80 (X3) on the particle size (Y1), and cumulative percentage drug released after 1h (Y2). The optimization was performed using the desirability function and contour plots. The scanning electron microscopy (SEM) showed the nanoparticles as spherical in shape. The differential scanning calorimetry (DSC) analysis indicated that there was substantial crystallinity change in the nanoparticle compared with the pure drug. Ex-vivo mucoadhesion study showed that famotidine mucoadhesive nanoparticles possessed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Famotidine; Nanosuspension; Box-Behnken design; Mucoadhesion; Peptic ulcer.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000200007

Effect of Helicobacter pylori infection and acid blockade by lansoprazole on clarithromycin bioavailability
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Ortiz,R.A.M.; Calafatti,S.A.; Moraes,L.A.; Deguer,M.; Ecclissato,C.C.; Marchioretto,M.A.M.; Ribeiro,M.L.; Bernasconi,G.; Pedrazzoli Jr,J.
The effect of proton pump inhibitors and Helicobacter pylori infection on the bioavailability of antibiotics is poorly understood. We determined the effects of 5-day oral administration of 60 mg lansoprazole on the bioavailability of clarithromycin in individuals with and without H. pylori infection. Thirteen H. pylori-infected and 10 non-infected healthy volunteers were enrolled in a study with an open-randomized two-period crossover design and a 21-day washout period between phases. Plasma concentrations of clarithromycin in subjects with and without lansoprazole pre-treatment were measured by liquid chromatography coupled to a tandem mass spectrometer. Clarithromycin Cmax and AUC0-10 h were significantly reduced after lansoprazole administration. In...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clarithromycin; Helicobacter pylori; Lansoprazole; Peptic ulcer; Pharmacokinetics.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300014

Fate of Helicobacter pylori artificially inoculated in lettuce and carrot samples
Provedor de dados: Brazilian Journal of Microbiology
Autores: Gomes,Bruna C.; Martinis,Elaine C.P. de.
Helicobacter pylori is known, worldwide, as the causative agent of gastric diseases. However, its transmission route has not been completely understood. To evaluate the survival of H. pylori (a clinical and a reference strain) artificially inoculated on lettuce and carrot samples, portions of 25 g were inoculated with approximately 10(6) CFU/g of H. pylori and packed under normal and/or modified atmosphere (3% oxygen, 10% carbon dioxide, and 87% nitrogen). The inoculated food samples were stored at 8ºC, with daily enumeration of H. pylori populations on Columbia blood agar (CBA) and/ or Helicobacter pylori Special Peptone Agar (HPSPA). When CBA with antibiotics was used, the clinical isolate H. pylori HP1 was detected for up to 72 h in sanitized lettuce...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: H. pylori; Peptic ulcer; Modified atmosphere; Vegetable.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000100024

Investigation of the association between clinical outcome and the cag pathogenicity-island and other virulence genes of Helicobacter pylori isolates from patients with dyspepsia in Eastern Turkey
Provedor de dados: Brazilian Journal of Microbiology
Autores: Ozbey,Gokben; Demirel,Ulvi; Aygun,Cem; Ertas,Hasan Basri.
The aims of our work were to determine the presence of the cag pathogenicity-island (cag PAI) and other virulence genes of Helicobacter pylori recovered from patients with gastritis and peptic ulcer, and to investigate the correlation of these virulence genes with clinical outcome. The presence of the cagA, the promoter regions of cagA, cagE, cagT, and the left end of cag-PAI (LEC), cag right junction (cagRJ), the plasticity region open reading frames (ORFs), vacA and oipA genes among 69 H. pylori isolates were determined by polymerase chain reaction. Intact cag PAI was detected in only one (1.4%) isolate. The cagA gene was identified in 52.1% and 76.2% of isolates from patients with dyspepsia (gastritis and peptic ulcer), respectively. The plasticity...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Helicobacter pylori; Gastritis; Peptic ulcer; Cag pathogenicity-island; Polymerase chain reaction.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000400034

Primary gastric fundus tuberculosis in immunocompetent patient: a case report and literature review
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Khan,Fahmi Yousef; AlAni,Ahmed; Al-Rikabi,Ammar; Mizrakhshi,A.; Osman,Mohamed El-Mudathir.
We report on a 29-year-old Pakistani man who presented to the clinic with epigastric pain, of one-month duration. He did not report fever, cough, vomiting blood, passing black stools, loss of appetite or diarrhea. However, he had lost 7 kg since his symptoms had begun. Clinical examination was unremarkable. Laboratory results were within normal limits. An abdominal CT scan showed a mass with enhancement in the stomach. Gastric endoscopy revealed an ulcerative mass in the fundus. An endoscopic-biopsy specimen revealed caseating granulomas with acid-fast bacilli. The patient was diagnosed to have primary gastric tuberculosis, and antituberculous medications were initiated. Cultures of the gastric mass subsequently grew Mycobacterium tuberculosis sensitive to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gastric tuberculosis; Hematemesis; Peptic ulcer; Stomach perforation.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500020

To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Hajiaghamohammadi,Ali Akbar; Zargar,Ali; Oveisi,Sonia; Samimi,Rasoul; Reisian,Sedigheh.
ABSTRACT  Objective: The aim of this study was to evaluate the effect of licorice in H. pylori eradication in patients suffering from dyspepsia either with peptic ulcer disease (PUD) or non-ulcer dyspepsia (NUD) in comparison to the clarithromycin-based standard triple regimen.  Methods: In this randomized controlled clinical trial, 120 patients who had positive rapid urease test were included and assigned to two treatment groups: control group that received a clarithromycin-based triple regimen, and study group that received licorice in addition to the clarithromycin-based regimen for two weeks. H. pylori eradication was assessed six weeks after therapy. Data was analyzed by chi-square and t-test with SPSS 16 software.  Results: Mean ages and SD were 38.8...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Helicobacter pylori; Licorice; Dyspepsia; Peptic ulcer.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600534