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EFFECTS OF PYRAZINAMIDE ON PREGNANT ALBINO RATS International Journal of Morphology
Pascale Quintino,Marisa; Simões,Manuel de Jesus; Uchiyama Nakamura,Mary; Martins Oliveira-Filho,Ricardo; Espiridião,Silvia; Kulay Júnior,Luiz.
Although being used for years in the treatment of tuberculosis, no data are available in the literature on the safety of pyrazinamide during pregnancy. Accordingly, we aimed to make a first approach to this problem by evaluating the effects of this drug administered during the entire pregnancy of albino rats. Fourty female, EPM-1 Wistar albino rats of about 250 g b.w. were used. Upon conception (day zero of pregnancy) the animals were randomly divided in 4 groups of 10 rats each and labeled as follows. Controls (C), animals treated with the drug vehicle (destilled water); experimental groups (E1, E2 and E3), animals treated with 35, 105 or 315 mg/kg b.w. pyrazinamide by gavage (oral route) once daily up to the term (20th day of pregnancy). Drug or vehicle...
Tipo: Journal article Palavras-chave: Pyrazinamide; Toxicology; Rat; Pregnancy.
Ano: 2003 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000400007
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Efficacy of cytology for the diagnosis of Chlamydia trachomatis in pregnant women BJID
Cornetta,Maria da Conceição de Mesquita; Gonçalves,Ana Katherine da Silveira; Bertini,Anna Maria.
This study evaluated the effectiveness of Papanicolaou staining for the initial diagnosis of Chlamydial infection in pregnant women. A hundred thirteen patients were examined with a Papanicolaou test, independent of gestational age, parity or maternal age. Three endocervical samples were collected; the first two were collected with a brush (Cytobrush plus, Mediscand, Sweden) and the third with Ayre's spatula. The first specimen was used for McCoy cell culture and the other two were examined cytologically. Chlamydial infection was detected in 9 (7.9%) patients. Only one (0.8%) was diagnosed by cytological exam. The sensitivity and specificity of the cytological examination were 10 and 98%, respectively. The estimated positive predictive value was 33.3% and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chlamydia trachomatis; Pregnancy; Infection; And cervical cytology.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500007
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Embriotoxic effects of maternal exposure to Tityus serrulatus scorpion venom J. Venom. Anim. Toxins incl. Trop. Dis.
Barão,A. A. S.; Nencioni,A. L. A.; Dorce,V. A. C..
Tityus serrulatus is the most venomous scorpion in Brazil; however, it is not known whether its venom causes any harm to the offspring whose mothers have received it. This study investigates whether the venom of T. serrulatus may lead to deleterious effects in the offspring, when once administered to pregnant rats at a dose that causes moderate envenomation (3mg/kg). The venom effects were studied on the 5th and on the 10th gestation day (GD5 and GD10). The maternal reproductive parameters of the group that received the venom on GD5 showed no alteration. The group that received the venom on GD10 presented an increase in post-implantation losses. In this group, an increase in the liver weight was also observed and one-third of the fetuses presented...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion venom; Perinatal; Tityus serrulatus; Pregnancy; Embryofetotoxicity.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000200010
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Energetic metabolism in fasting sheep: regularization of metabolic profile by treatment with oral glucose, with prior handling of gastric groove R. Bras. Zootec.
Martín-Alonso,María José; Escalera-Valente,Francisco; Cal-Pereyra,Luis G.; Benech,Alejandro; Alonso,María Pilar; González-Montaña,José Ramiro.
ABSTRACT The objective of this research was to evaluate a possible corrective measure against negative metabolic states, as occurs in the advanced stage of gestation in ewes, and that sometimes produces a disease called pregnancy toxaemia. In the present research, we found that the joint administration of i.v. lysine-vasopressin (0.08 IU/kg body weight, BW) and an oral glucose solution (50 g) produces an increase in blood glucose, which persists for some time (up to 6 h); therefore, it could be used in the treatment of pregnancy toxaemia. This therapy is based on the fact that lysine-vasopressin induces gastric groove closure in adult ruminants, enabling orally administered glucose to reach the abomasum directly, from where it rapidly passes into the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ewes; Gastric groove; Glycaemia; Metabolism; Pregnancy; Toxaemia; Vasopressin.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982019000100723
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Enhanced expression of Ang-(1-7) during pregnancy BJMBR
Brosnihan,K.B.; Neves,L.A.A.; Anton,L.; Joyner,J.; Valdes,G.; Merrill,D.C..
Pregnancy is a physiological condition characterized by a progressive increase of the different components of the renin-angiotensin system (RAS). The physiological consequences of the stimulated RAS in normal pregnancy are incompletely understood, and even less understood is the question of how this system may be altered and contribute to the hypertensive disorders of pregnancy. Findings from our group have provided novel insights into how the RAS may contribute to the physiological condition of pregnancy by showing that pregnancy increases the expression of both the vasodilator heptapeptide of the RAS, angiotensin-(1-7) [Ang-(1-7)], and of a newly cloned angiotensin converting enzyme (ACE) homolog, ACE2, that shows high catalytic efficiency for Ang II...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pregnancy; Renin-angiotensin system; Preeclampsia; Angiotensin-(1-7).
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800017
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Epidemiologic and clinical characteristics of pregnant women living with HIV/AIDS in a region of Southern Brazil where the subtype C of HIV-1 infection predominates BJID
Manenti,Sandra Aparecida; Galato Júnior,João; Silveira,Elizângela da Silva; Oenning,Roberto Teixeira; Simões,Priscyla Waleska Targino de Azevedo; Moreira,Jeverson; Fochesato,Celine Maria; Brígido,Luís Fernando de Macedo; Rodrigues,Rosângela; Romão,Pedro Roosevelt Torres.
Southern Brazil has the highest prevalence rate of AIDS in the country and is the only region in the Americas where HIV-1 subtype C prevails. OBJECTIVE: We evaluated the epidemiologic and clinical characteristics of pregnant women living with HIV/AIDS in the South region of Santa Catarina, Brazil. METHODS: All pregnant women with HIV infection attending the obstetric outpatient clinic of Criciúma, State of Santa Catarina, in 2007 (n = 46) were invited to participate. Data of 36 eligible participants were obtained through a standardized questionnaire. RESULTS: The great majority were young, with a steady partner, low family income, low education level and referring early first sexual intercourse. Many reported use of illicit non-injecting drugs (55.5%) and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: AIDS; Serodiagnosis; HIV infections; Pregnancy; HIV-1 subtype C; Southern Brazil.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400008
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Estimation methods and correction factors for body weight in Mangalarga Marchador horses R. Bras. Zootec.
Souza,Felipe Amorim Caetano de; Muniz,Joel Augusto; Fernandes,Tales Jesus; Cunha,Fabiana Oliveira; Meirelles,Sarah Laguna Conceição; Souza,José Camisão de; Moura,Raquel Silva de.
ABSTRACT The objective was to evaluate the accuracy of six body weight (BW) estimating methods in Mangalarga Marchador horses (MM) (n = 318): method A - tape placements at three different positions around the thoracic girth; B - Crevat and Quetelec's formula; C - Hall's formula; D - Hintz and Griffiths’ table; E - Santos’ table; and F - Cintra's formula. For additional analyses, gender, age, and gestational stage were considered. Estimated average BW was compared to the actual scale weight by the paired T test, mean predicted error, and determination coefficient. In the general population, methods A (position 3), B, and C estimated BW that were different from that of the scale. Method A, at positions 1 and 2, was more accurate in predicting the scale...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Animal production; Equine; Foal; Nutrition; Pregnancy.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982017001200903
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Evaluation of Placental Epigenetic Changes due to Morphine Consumption International Journal of Morphology
Kazemi,Masoomeh; Tekieh,Elaheh; Golabi,Sahar; Sahraei,Hedayat.
Based on previous studies, a variety of bioenvironmental elements including inappropriate nutrition, diseases, infections, stressors, and medications are involved in epigenetic changes. Drug abuse is one of the most important causes of epigenetic changes and a concern in today's world. Studies have shown that morphine use by pregnant mothers causes several disorders in mothers in addition to transferring abnormalities to the next generation (placenta and embryo). Epigenetic factors such as morphine cause changes in gene expression in placenta as the first embryonic defense barrier. Because placenta does all the nutritional exchanges between mother's and embryo's blood, placental health guarantees normal embryonic development. Many studies have been...
Tipo: Journal article Palavras-chave: Development; Morphine; Embryo; Epigenetic; Pregnancy; Placenta.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100036
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Foscarnet Effects on the Rat Pregnancy Outcome International Journal of Morphology
Venneri Mathias,Cícero; Simões,Manuel de Jesus; Mahmed Amed,Abes; Martins Oliveira-Filho,Ricardo; Venneri Mathias,Camila Fernandes; dos Santos Simões,Ricardo; Kulay Júnior,Luiz.
There are few long-term data on which to base decisions of drug management of HIV infection in pregnancy. The determination of safe medications must take into consideration the need for certain drugs and the possibility of inadvertent fetal exposure because of unplanned pregnancies. The aim of this study was to evaluate the effects of foscarnet on the entire period of rat pregnancy. Female pregnant rats were randomly assigned to four treatment groups (n = 10): one control (C) ­ treated with the drug vehicle (bidestilled water) and three experimental groups (E1, E2 and E3) ­ treated with 180, 360 or 720 mg/Kg of foscarnet, respectively. Rats were treated by gavage once daily. The treatment period extended from the first until the 20th day of pregnancy. Body...
Tipo: Journal article Palavras-chave: Antiretroviral drugs; Foscarnet; Pregnancy; Rat.
Ano: 2005 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000200008
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From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America Genet. Mol. Biol.
Schüler-Faccini,Lavinia; Sanseverino,Maria Teresa Vieira; Abeche,Alberto Mantovani; Vianna,Fernanda Sales Luiz; Fraga,Lucas Rosa; Rocha,Anastacia Guimaraes; Silva,André Anjos da; Souza,Paulo Ricardo Assis de; Hilgert,Artur Hartmann; Barbosa,Camila Pocharski; Kauppinem,Caroline Grasso; Martins,Daniela Fernandes; Santos,Daniela Silva; Colpes,Gabriel Henrique; Ecco,Gabriela; Silva,Helena Margot Flores Soares da; Penteado,Louise Piva; Santos,Tatiane dos.
Abstract In 1990, the first Teratogen Information Service in Brazil (SIAT) was implemented in the Medical Genetics Service at Hospital de Clinicas de Porto Alegre. SIAT is a free-to-use information service both to health professionals and the general population, especially to women who are pregnant or planning pregnancy. The main objective of this paper is to present the activities of SIAT in its initial years (1990-2006), compared to those in the last decade (2007-2017). In addition we review the scientific contribution of SIAT in the field of human teratogenesis. Since 1990, SIAT received 10,533 calls. Use of medications were the main reason for concern, accounting for 74% of all questions, followed by other chemical exposures (occupational, cosmetics,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Teratogens; Pregnancy; Zika; Thalidomide; Misoprostol; Rubella.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200297
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Gene expression of estrogen and oxytocin receptors in the uterus of pregnant and parturient bitches BJMBR
Veiga,G.A.L.; Milazzotto,M.P.; Nichi,M.; Lúcio,C.F.; Silva,L.C.G.; Angrimani,D.S.R.; Vannucchi,C.I..
In the canine species, the precise mechanisms of pregnancy maintenance and the initiation of parturition are not completely understood. The expression of genes encoding the receptors for estrogen (ERα mRNA) and oxytocin (OTR mRNA) was studied in the endometrium and myometrium during pregnancy and parturition in dogs. Real-time PCR was performed to quantify the levels of ERα mRNA and OTR mRNA in the uterus of bitches during early (up to 20 days of gestation), mid (20 to 40 days) and late pregnancy (41 to 60 days), and parturition (first stage of labor). All tissues expressed ERα and OTR mRNA, and are thus possibly able to respond to eventual estrogen and oxytocin hormonal stimuli. No statistically significant differences in the expression of ERα mRNA were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Canine; Estrogen; Oxytocin; Receptors; Pregnancy; Parturition.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400339
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Gestational toxoplasmosis in Paraná State, Brazil: prevalence of IgG antibodies and associated risk factors BJID
Lopes-Mori,Fabiana Maria Ruiz; Mitsuka-Breganó,Regina; Bittencourt,Laura Helena França de Barros; Dias,Renata Cristina Ferreira; Gonçalves,Daniela Dib; Capobiango,Jaqueline Dario; Reiche,Edna Maria Vissoci; Morimoto,Helena Kaminami; Freire,Roberta Lemos; Navarro,Italmar Teodorico.
The aim of the present study was to verify the association between seropositivity for IgG anti-Toxoplasma gondii antibodies and social, economic and environmental variables of pregnant women attending the public health centers of Paraná, Brazil. From January 2007 to July 2010, 2226 pregnant women were interviewed and detection of anti-T. gondii specific IgG and IgM antibodies was performed by chemiluminescence test. Seropositivity for anti-T. gondii IgG was observed in 1151 (51.7%) pregnant women, 29 of which (1.3%) presented IgM reagent with IgG of high avidity. The variables associated with the presence of IgG were residency in the rural area, more than one pregnancy, less than or equal to eight years schooling, low per capita income, age group, raw or...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Seroepidemiology; Prevalence; Toxoplasmosis; Pregnancy.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400004
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GnRH application in cows with low or no estrus expression evaluated with tail-chalk increases the pregnancy rate in beef cows submitted to TAI. Repositório Alice
NOGUEIRA, E.; RODRIGUES, W. B.; SILVA, A. S.; SILVA, J. C. B. da; SILVA, K. C.; ANACHE, N. A.; BEZERRA, A. O.; LEÃO, B. C. S.; ROCHA-FRIGONI, N. A. S.; MINGOTI, G. Z..
The objective was to evaluate the GnRH application in cows with low or poor estrus expression evaluated using tail chalk removal Score (ESCT) to increase TAI pregnancy rates.
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Tail-chalk; GnRH; Prenhez; Reprodução animal; Pregnancy; Animal repdroduction.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1055128
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Group B Streptococcus detection: comparison of PCR assay and culture as a screening method for pregnant women BJID
de-Paris,Fernanda; Machado,Alice Beatriz Mombach Pinheiro; Gheno,Tailise Conte; Ascoli,Bruna Maria; Oliveira,Kátia Ruschel Pilger de; Barth,Afonso Luis.
Streptococcus agalactiae or group B Streptococcus (GBS) is one of the most important causal agents of serious neonatal infections. Numerous assays have been evaluated for GBS screening in order to validate a fast and efficient method. The aim of this study was to compare the culture technique (established as the gold standard) with the molecular method of polymerase chain reaction (PCR) with specific primers (atr gene). Two hundred and sixty-three samples were analyzed. Vaginal samples were collected, according to the Centers for Disease Control and Prevention (CDC) recommendations, from women over 35 weeks of pregnancy at Hospital de Clínicas de Porto Alegre (HCPA). Two different extraction methods were tested in all samples collected. PCR technique...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Streptococcus agalactiae; Polymerase chain reaction; Culture; Pregnancy.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400004
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Handling of female pacas (Agouti paca, Linnaeus, 1766) for ultrasound pregnancy detection Braz. J. Vet. Res. Anim. Sci.
Oliveira,Fabrício Singaretti de; Machado,Márcia Rita Fernandes; Canola,Júlio Carlos.
The paca is a South American rodent whose handling, tranquilization or anesthesia offers a large field of research due to rare existing issues. Twelve adult female pacas were used, separated in 6 pen, and were caught with a net made of polypropylene attached to a wire loop and then sent to a room where the abdominal hair clipping was done. Afterwards, the female was placed in an iron bar squeeze cage. The ultrasonography session was made in B mode with a two-frequency sectorial electronic transducer of 5.0 and 7.5 MHz. Intending to reduce the stress caused by the procedures, the tranquilization of females was made with oral taking of diazepam and midazolam maleate. Both presented effectiveness in tranquilization of pacas previously and during sessions,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Paca; Handling; Pregnancy.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95962003000100008
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hCG administration in Saanem goats inseminated following synchronized estrus. Repositório Alice
FONSECA, J. F. da; MATOS, L. M.; ZAMBRINI, F. N.; FERREIRA, M. I. C.; FACO, O..
2014
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Sincronização do estro; Raça Saanen; HCG; Caprino; Reprodução animal; Indução; Sincronicação do cio; Ciclo estral; Prenhez; Hormônio animal; Goats; Reproduction; Artificial insemination; Oestrus synchronization; Pregnancy; Oestrous cycle.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/993416
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Heat score accessed with aid of tail-chalk influences pregnancy rate of suckled Bos indicus beef cows subjected to P4/estradiol TAI-based protocols. Repositório Alice
SILVA, K. C.; RODRIGUES, W. B.; SILVA, A. S.; SILVA, J. C. B. da; ABREU, U. G. P. de; BATISTA, D. S. do N.; ANACHE, N. A.; BEZERRA, A. O.; JARA, J. do P.; NOGUEIRA, E..
It is known that cows that express estrus submitted to TAI protocols, have better pregnancy rates (Borges et al. 2011). So the goal was to test alternative to visual estrus observation, evaluating the effect of estrus expression with the assistance of tail-chalk on pregnancy rates and the pre-ovulatory follicle diameter in beef cows submitted to TAI protocols with use of two ovulation inducers: estradiol benzoate (EB) and estradiol cypionate (ECP).
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Follicular diameter; Inducers; Heat detection; Reprodução animal; Prenhez; Animal reproduction; Pregnancy.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1055122
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Hematological and biochemical profiles of Mangalarga Marchador mares in the transition period bred on pasture Arq. Bras. Med. Vet. Zootec.
Silva,M.O.; Ribeiro Filho,J.D.; Dantas,W.M.F.; Valente,F.L.; Ribeiro,B.M.; Ermita,P.A.N.; Monteiro,L.C.; Costa,C.M.; Silva,G.M.M.; Alves,S.R.; Avanza,M.F.B.; Santos,P.V.M.; Manso Filho,H.C..
ABSTRACT The present study aimed to evaluate the effects of the transition period on hematological and biochemical constituents in Mangalarga Marchador mares. Forty-eight mares were used to form a maintenance group (MG) and transition group (TG), formed by pregnant mares and, after delivery, infants. Blood samples were collected at the following times: T-60 (60 d pre-delivery), T-30 (30 d pre-delivery), T-15 (15 d pre-delivery), T0 (first 6h post-delivery), T15 (15 d post-delivery), T30 (30 d post-delivery), and T60 (60 d post-delivery). The TG had lower values (P< 0.05) of red blood cells, hematocrit and hemoglobin at T0, T15, T30 and T60 times than MG. The mean corpuscular volume was lower in MG (P< 0.05) than in TG (T0, T15, T30 and T60) and mean...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Equine; Blood count; Lactation; Pregnancy; Peripartum.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000601765
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Hemodynamic gestational adaptation in bitches Ciência Rural
Almeida,Vívian Tavares de; Uscategui,Ricardo Andres Ramirez; Silva,Priscila Del Aguila da; Avante,Michele Lopes; Simões,Ana Paula Rodrigues; Vicente,Wilter Ricardo Russiano.
ABSTRACT: Throughout pregnancy, maternal hemodynamic adaptation is needed to ensure proper uterine perfusion and fetal development. When the uteroplacental vascular system is formed, starting with reduced resistance to uterine arterial flow, this results in decreased total vascular resistance, an activation of neuroendocrine vasoactive peptides, an increase in circulating blood and changes in the cardiovascular system morphophysiology to respond to the increasing demands of uterine perfusion. There has been considerable study of hemodynamic adaptation in pregnant women and this assessment has become a diagnostic tool for fatal obstetric disorders. However, in bitches the available information in this regard is limited; therefore a parallel was drawn...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiovascular; Pregnancy; Gestation; Morphophysiology; Dogs.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000700601
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Histological characteristics of the corpus luteum of Nelore cows in the first, second and third trimester of pregnancy Arq. Bras. Med. Vet. Zootec.
Xavier,P.R.; Leão,R.A.C.; Oliveira e Silva,P.V.D.; Marques Júnior,A.P..
Foram avaliadas características morfológicas do corpo lúteo de 48 vacas Nelore gestantes obtidos de abatedouros. Os ovários com o corpo lúteo foram coletados, identificados e divididos em três grupos, considerando o estágio da gestação determinado pelo tamanho do feto: Grupo I - onze animais com gestação até 90 dias; Grupo 2 - vinte animais com gestação de 90 a 180 dias, e Grupo 3 - 17 animais com gestação de 180 a 261 dias. Todos os corpos lúteos foram dissecados, submetidos a processamento histológico e avaliados utilizando microscopia de luz. As características morfológicas das células luteais esteroidogênicas não mudou durante a gestação. Porém, foi observado um aumento de tecido conjuntivo, fibroblastos e matriz extracelular durante o final da...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nelore cow; Pregnancy; Corpus luteum; Secretion granules.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000200036
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