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| CUDDON,PAUL; BOOTMAN,MARTIN D; RICHARDS,GILLIAN R; SMITH,ALISON J; SIMPSON,PETER B; RODERICK,H LLEWELYN. |
| Neurons are a diverse cell type exhibiting hugely different morphologies and neurotransmitter specifications. Their distinctive phenotypes are established during differentiation from pluripotent precursor cells. The signalling pathways that specify the lineage down which neuronal precursor cells differentiate remain to be fully elucidated. Among the many signáis that impinge on the differentiation of neuronal cells, cytosolic calcium (Ca2+) has an important role. However, little is known about the nature of the Ca2+ signáis involved in fate choice in neuronal precursor cells, or their sources. In this study, we show that activation of either muscarinic or platelet-derived growth factor (PDGF) receptors induces a biphasic increase in cytosolic Ca2+ that... |
| Tipo: Journal article |
Palavras-chave: Ca2+; PDGF; Methacholine; TRPC6; SOCE; Human neurosphere-derived cells. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200008 |
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