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Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin BABT
Almeida,Danielle Ayr Tavares de; Braga,Camila Pereira; Novelli,Ethel Lourenzi Barbosa; Fernandes,Ana Angélica Henrique.
The present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Vitamin E; Lipid profile; Oxidative stress; STZ.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000400007
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Antioxidant Effects of Biochanin A in Streptozotocin Induced Diabetic Rats BABT
Sadri,Hamideh; Goodarzi,Mohammad Taghi; Salemi,Zahra; Seifi,Morteza.
ABSTRACT Bioflavonoid-containing diets have been reported to be beneficial in diabetes. In the current study, the effect of Biochanin A (BCA) on blood glucose, antioxidant enzyme activities and oxidative stress markers in diabetic rats were investigated. 30 male Wistar rats were divided into five groups. Two of them were selected as control; group1: control (receiving 0.5%DMSO), and group2: Control+BCA (receiving 10 mg/kg.bw BCA). Diabetes was induced in other rats with injection of (55 mg/kg.bw) streptozotocin; group3: diabetic control (receiving 0.5%DMSO), groups 4 and 5 were treated with 10 and 15 mg/kg.bw BCA respectively. After 6 weeks the following results were obtained. Fasting blood glucose (FBG), Triglyceride (TG), total cholesterol (TC), low...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Biochanin A; Diabetic rats; Oxidative stress; STZ.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100313
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