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| ALMEIDA, S. D. B. de; FRANCO, D. A. de S.; CERDEIRA, A. L.; QUEIROZ, S. C. do N. de; MATALLO, M. B.. |
| Abstract: Shikimic acid (SA) has witnessed a strong increase in recent years due to the increasing demand of the pharmaceutical and cosmetic industry. The SA is used as a precursor for the synthesis of oseltamivir phosphate (Tamiflu®), a potent viral inhibitor and is extracted from the plant Illicium verum Hook which has a limited availability. This article proposed the use of Urochloa plantaginea (Link.) webster and glyphosate, as an alternative source of SA. U. plantaginea plants with 3 - 4 tillers and 4 - 6 leaves were harvest at 3, 6, 9 and 12 days after application (DAT) of low rates of glyphosate. Samples were dried, extracted, analyzed by HPLC and LC-MS/MS. The maximum SA concentrations were observed at 6 days after glyphosate at 36 g.a.e.ha-1 was... |
| Tipo: Artigo de periódico |
Palavras-chave: Oseltamivir phosphate; 5-enol pyruvyl shikimate-3-phosphate synthase (EPSPs); Fosfato de oseltamivir; Anis estrelado; EPSPs; Brachiaria Plantaginea; Herbicida; Planta Medicinal; Anis; Oseltamivir; Influenza; Illicium verum; Glyphosate; Shikimic acid. |
| Ano: 2020 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1125411 |
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| COSTA, M. C. A.; MATALLO, M. B.; FERREIRA, M. M. C.; QUEIROZ, S. C. do N. de; ALMEIDA, S. D. B.; FRANCO, D. A. S.. |
| Abstract: Shikimic acid is a natural organic compound produced in the biochemical pathways of eukaryotic organisms and is generally utilized as a starting material of the antiviral drug Oseltamivir (Tamiflu®). This study shows the results of shikimic acid accumulation in Brachiaria plantaginea, an abundant, grassy plant found in Brazil and other countries in Africa and America, after glyphosate spraying at three different doses. B. plantaginea plants harvested after 6 days of exposure to the herbicide showed that shikimic acid accumulation increased by 345%, on average, compared to unsprayed plants. The combination of near infrared spectroscopy and multivariate analysis using partial least square regression was applied for the quantification of shikimic... |
| Tipo: Separatas |
Palavras-chave: NIR spectroscopy; PLS regression; Brachiaria plantaginea; Gramínea; Shikimic acid; Chemometrics. |
| Ano: 2016 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1066054 |
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| FRANCO, D. A. S.; ALMEIDA, S. D. B.; MOURA, M. A. M.; BOTTEON, J. E.; CERDEIRA, A. L.; QUEIROZ, S. C. do N. de; MATALLO, M. B.. |
| Resumo: Periodicamente a humanidade é assolada por pandemias de gripe com consequências fatais. Dessa forma, o desenvolvimento de medidas eficazes para combater as viroses é de crucial importância para a saúde humana. O fosfato de oseltamivir é um potente inibidor viral produzido a partir do ácido chiquímico e extraído da semente de llicium verum sua mais importante fonte natural. Tendo como sítio de ação a enzima 5-enolpiruvilchiquimato-3-fosfato sintae (EPSPs), glyflosate é o único composto capaz de inibir a sua atividade com o consequente acúmulo do ácido chiquímico pelos vegetais. Plantas de B. plantaginea foram pulverizadas com subdoses de glyflosate determinado-se o teor de ácido chiquímico na massa seca dessas plantas por HPLC aos 0, 3, 6, 9 e 12... |
| Tipo: Separatas |
Palavras-chave: Ácido chiquímico; HPLC; Brachiaria plantaginea; Herbicida; Análise química; Cromatografia; Influenza aviária; Shikimic acid; Glyphosate; High performance liquid chromatography. |
| Ano: 2014 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1006925 |
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| GAZOLA,T.; DIAS,M.F.; CARBONARI,C.A.; VELINI,E.D.. |
| ABSTRACT: The objective of this work was to monitor the resistance of sourgrass (Digitaria insularis) to glyphosate in urban areas of the State of São Paulo to understand the spread of resistant biotypes. Three experiments were conducted under greenhouse conditions in a completely randomized design, with four replications. In the first experiment, seven sourgrass biotypes were used, and the control of plants was evaluated at 7, 14, 21, 28, and 35 days after application (DAA) of glyphosate. In the second experiment, the shikimic acid accumulation was quantified at 72 hours after the glyphosate application, and the same evaluations of weed control were performed. In the third experiment, rate-response curves were developed, with glyphosate at rates of 0, 90,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Shikimic acid; Digitaria insularis; EPSPS; Resistance. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582019000100183 |
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| MATALLO, M. B.; ALMEIDA, S. D. B.; FRANCO, D. A. S.; CERDEIRA, A. L.; GAZZIERO, D. L. P.. |
| Resumo: O fosfato de oseltamivir, ingrediente ativo do antiviral Tamiflu®, é um potente inibidor viral produzido a partir do ácido chiquímico e extraído da semente de Ilicium verum, sua mais importante fonte natural. Tendo como sítio de ação a enzima 5 enolpiruvilchiquimato-3-fosfato sintase (EPSPs), o glyphosate é o único composto capaz de inibir a sua atividade, com o consequente acúmulo do ácido chiquímico nas plantas. Plantas de milho e soja foram pulverizadas com subdoses de glyphosate (0,0 a 230,4 g e.a. ha-1), determinando-se o teor de ácido chiquímico na massa seca dessas plantas por HPLC aos 3,7 e 10 dias após aplicação. Os resultados mostraram acúmulo de ácido chiquímico na massa seca dessas plantas, com aumento de até 969% no milho e 33.000% na... |
| Tipo: Separatas |
Palavras-chave: Fosfato de oseltamivir; Pandemias; HPLC; Ácido chiquímico; Herbicida; Milho; Soja; Biossíntese; Glyphosate; Soybeans; Corn; Shikimic acid; Biosynthesis. |
| Ano: 2014 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1009752 |
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| Vargas,L.; Silva,D.R.O.; Agostinetto,D.; Matallo,M.B.; Santos,F.M.; Almeida,S.D.B.; Chavarria,G.; Silva,D.F.P.. |
| The objective of this study was to determine changes in gas exchange and inhibition of EPSPs, based on the accumulation of shikimic acid in horseweed biotypes resistant and sensitive to glyphosate. Two experiments were conducted in a factorial model. The first one evaluated horseweed biotypes (one resistant and one susceptible to glyphosate), and herbicide rates (0 and 1,080 g a.e. ha ¹) applied on the weed. In the second experiment, the horseweed biotypes (susceptible and resistant to glyphosate) were evaluated in five periods as following: 0, 3, 7, 10, and 14 days after herbicide application (DAH). The photosynthetic rate, transpiration, carboxylation efficiency, and water efficiency were determined using an infrared gas analyzer (IRGA), and shikimic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hairy fleabane; Resistance; Photosynthesis; EPSPs; Shikimic acid. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582014000100017 |
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