Consulta: subjectFacets:"Submandibular gland"
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Data/hora: 27/07/2024 03:16:51

MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLAND
Provedor de dados: International Journal of Morphology
Autores: Siéssere,Selma; Semprini,Marisa; Lopes,Ruberval A; Sala,Miguel A; Mattos,Maria G. C.
Valproic acid, an antiepileptic drug, is a well-known teratogenic agent; its main target organ is the neural tube, though organ malformations have also been described. The aim of the present work was to analyze the effects of valproic acid on embryo/fetal oral structures: Meckel's cartilage, muscles of the tongue, and submandibular gland. Rats received a intraperitoneal injected of Valproic acid (300mg/Kg) on the 10th day of their gestation. Females were sacrificed on day 20 post coitus, and fetuses were examined. No gross malformations were observed. The following morphological alterations were observed: lower body and placental weight; shorter umbilical cord length; submandibular gland parenchyma less differentiated with larger cellular cord and terminal...
Tipo: Journal article
Palavras-chave: Valproic acid; Rat; Meckel's cartilage; Lingual musculature; Submandibular gland.
Ano: 2004
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200006

Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Fernandez-Solari,J.; Prestifilippo,J.P.; Vissio,P.; Ehrhart-Bornstein,M.; Bornstein,S.R.; Rettori,V.; Elverdin,J.C.
Our objective was to determine the effect of arachidonylethanolamide (anandamide, AEA) injected intracerebroventricularly (icv) into the lateral ventricle of the rat brain on submandibular gland (SMG) salivary secretion. Parasympathetic decentralization (PSD) produced by cutting the chorda tympani nerve strongly inhibited methacholine (MC)-induced salivary secretion while sympathetic denervation (SD) produced by removing the superior cervical ganglia reduced it slightly. Also, AEA (50 ng/5 µL, icv) significantly decreased MC-induced salivary secretion in intact rats (MC 1 µg/kg: control (C), 5.3 ± 0.6 vs AEA, 2.7 ± 0.6 mg; MC 3 µg/kg: C, 17.6 ± 1.0 vs AEA, 8.7 ± 0.9 mg; MC 10 µg/kg: C, 37.4 ± 1.2 vs AEA, 22.9 ± 2.6 mg). However, AEA did not alter the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anandamide; Parasympathetic nervous system; Submandibular gland; Cannabinoid receptor type 1; Gamma-aminobutyric acid.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600010

Localization of Cannabinoid Receptor 1 (CB1) in Submandibular and Sublingual Salivary Glands of Mice throughout Postnatal Development
Provedor de dados: International Journal of Morphology
Autores: Hipkaeo,Wiphawi; Watanabe,Masahiko; Kondo,Hisatake.
In view of the fact that human marijuana users often show dry mouth symptom, the present study was attempted to examine the localization of CB1, which was originally identified in brain, in the submandibular and sublingual salivary glands of postnatal developing male mice by immunohistochemistry. In submandibular gland, CB1-immunoreactivity was positive in a majority of acinar cells in forms of granular appearance in their apical cytoplasm, while it was negative in the ducts at newborn stage. The immunoreactivity decreased in the acinar cells at P1W and no immunoreactivity was detected in the acinar cells at P3W and thereafter. The immunoreactivity was positive in ductal cells at P3W and it remained positive thereafter until P8W stage. The immunoreaction...
Tipo: Journal article
Palavras-chave: Cannabinoid receptor 1; Immunohistochemistry; Submandibular gland; Sublingual gland; Postnatal mice.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200044