Consulta: subjectFacets:"Temporal lobe epilepsy"
Registros recuperados: 4
Data/hora: 26/07/2024 22:44:38

The pilocarpine model of epilepsy: what have we learned?
Provedor de dados: Anais da Academia Brasileira de Ciências
Autores: Scorza,Fulvio A.; Arida,Ricardo M.; Naffah-Mazzacoratti,Maria da Graça; Scerni,Débora A.; Calderazzo,Lineu; Cavalheiro,Esper A.
The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hippocampus; Pilocarpine; Temporal lobe epilepsy; Rat.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300003

EEG spike source localization before and after surgery for temporal lobe epilepsy: a BOLD EEG-fMRI and independent component analysis study
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Sercheli,M.S.; Bilevicius,E.; Alessio,A.; Ozelo,H.; Pereira,F.R.S.; Rondina,J.M.; Cendes,F.; Covolan,R.J.M.
Simultaneous measurements of EEG-functional magnetic resonance imaging (fMRI) combine the high temporal resolution of EEG with the distinctive spatial resolution of fMRI. The purpose of this EEG-fMRI study was to search for hemodynamic responses (blood oxygen level-dependent - BOLD responses) associated with interictal activity in a case of right mesial temporal lobe epilepsy before and after a successful selective amygdalohippocampectomy. Therefore, the study found the epileptogenic source by this noninvasive imaging technique and compared the results after removing the atrophied hippocampus. Additionally, the present study investigated the effectiveness of two different ways of localizing epileptiform spike sources, i.e., BOLD contrast and independent...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Interictal epileptiform spike; Epilepsy surgery; EEG-fMRI; Temporal lobe epilepsy; ICA; Dipole model.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600017

SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Li,Rong; He,Miaoqing; Wu,Bing; Zhang,Peng; Zhang,Qinbin; Chen,Yangmei.
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission. It is widely accepted that AMPA receptors are critical for the generation and spread of epileptic seizure activity. Dysfunction of AMPA receptors as a causal factor in patients with intractable epilepsy results in neurotransmission failure. Brain-specific serine/threonine-protein kinase 1 (SAD-B), a serine-threonine kinase specifically expressed in the brain, has been shown to regulate AMPA receptor-mediated neurotransmission through a presynaptic mechanism. In cultured rat hippocampal neurons, the overexpression of SAD-B significantly increases the frequency of miniature excitatory postsynaptic currents...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: SAD-B; AMPA receptor; Temporal lobe epilepsy; PTZ.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000400602

Relative frequency, clinical, neuroimaging, and postsurgical features of pediatric temporal lobe epilepsy
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Sales,L.V.; Velasco,T.R.; Funayama,S.; Ribeiro,L.T.; Andrade-Valença,L.P.; Neder,L.; Fernandes,R.M.F.; Araujo Jr.,D.; Machado,H.R.; Santos,A.C.; Leite,J.P.
We describe the relative frequency, clinical features, neuroimaging and pathological results, and outcome after pharmacological or surgical intervention for a series of pediatric patients with temporal lobe epilepsy (TLE) from an epilepsy center in Brazil. The medical records of children younger than 12 years with features strongly suggestive of TLE were reviewed from January 1999 to June 1999. Selected children were evaluated regarding clinical, EEG, and magnetic resonance imaging (MRI) investigation and divided into three groups according to MRI: group 1 (G1, N = 9), patients with hippocampal atrophy; group 2 (G2, N = 10), patients with normal MRI, and group 3 (G3, N = 12), patients with other specific temporal lesions. A review of 1732 records of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Temporal lobe epilepsy; Children; Etiology; Prognosis; Developing countries.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001000013