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Efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis 58
Meinerz,Ana Raquel Mano; Xavier,Melissa O.; Cleff,Marlete Brum; Madrid,Isabel Martins; Nobre,Márcia Oliveira; Meireles,Mário Carlos Araújo; Mello,João Roberto Braga de.
Itraconazole is currently considered the drug of choice to treat the diverse clinical presentation of sporotrichosis. On the other hand terbinafine by virtue of its excellent in vitro activity is under comparative evaluation for its therapeutic potential for a wide range of fungal infections. In this study, our aim was to determine the in vivo efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis. 120 rats Wistar received an injection of 2x10³ S. schenckii cells by via the lateral tail vein. After 3 days the animals were treated with terbinafine (250mg/kg) and itraconazole (100 mg/kg) and their respective diluents. In our model, terbinafine and itraconazole were effective in reducing the number of clinical lesions and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Itraconazole; Terbinafine; Sporotrichosis; Antifungal.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000400025
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In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes 60
Lana,Aline Jacobi Dalla; Pippi,Bruna; Carvalho,Anderson Ramos; Moraes,Renata Cougo; Kaiser,Samuel; Ortega,George Gonzalez; Fuentefria,Alexandre Meneghello; Silveira,Gustavo Pozza.
ABSTRACT Griseofulvin (GF) and terbinafine (TF) are commonly used drugs to treat dermatophytosis, a fungal infection of the skin. Today there is an increase in drug resistance to these antifungals which highlight the need for alternative synergistic therapies. Minimum Inhibitory Concentration (MIC) of GF and TF were determined against fungi clinical isolates from local hospitals with values ranging 0.03-2.0 µg mL-1 and 0.24-4.0 µg mL-1, respectively. A checkboard test was used to determine the combination of GF:TF which could induce an additive effect against the fungi isolates Multidrug-resistant isolates showed susceptibility after treatment with 16:2 µg mL-1 GF:TF. An MTT assay further verified that GF and TF combinations have greater additive effect...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Griseofulvin; Terbinafine; Dermatophyte; Multidrug-resistant fungi; Drug combination..
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200623
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