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Follow-up of patients treated with retinoic acid for the control of radioiodine non-responsive advanced thyroid carcinoma BJMBR
Coelho,S.M.; Vaisman,F.; Buescu,A.; Mello,R.C.R.; Carvalho,D.P.; Vaisman,M..
During thyroid tumor progression, cellular de-differentiation may occur and it is commonly accompanied by metastatic spread and loss of iodine uptake. Retinoic acid (RA) administration might increase iodine uptake in about 40% of patients, suggesting that RA could be a promising therapeutic option for radioiodine non-responsive thyroid carcinoma, although a prospective study with a long-term follow-up has not been reported. This was a clinical prospective study assessing the value of 13-cis-RA in patients with advanced thyroid carcinoma and its impact on major outcomes such as tumor regression and cancer-related death with a long-term follow-up of patients submitted to radioiodine (131I) therapy after RA administration. Sixteen patients with inoperable...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Thyroid cancer; Retinoic acid; Radioiodine therapy.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000100011
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Iodine-131 treatment of thyroid cancer cells leads to suppression of cell proliferation followed by induction of cell apoptosis and cell cycle arrest by regulation of B-cell translocation gene 2-mediated JNK/NF-κB pathways BJMBR
Zhao,L.M.; Pang,A.X..
Iodine-131 (131I) is widely used for the treatment of thyroid-related diseases. This study aimed to investigate the expression of p53 and BTG2 genes following 131I therapy in thyroid cancer cell line SW579 and the possible underlying mechanism. SW579 human thyroid squamous carcinoma cells were cultured and treated with 131I. They were then assessed for 131I uptake, cell viability, apoptosis, cell cycle arrest, p53 expression, and BTG2 gene expression. SW579 cells were transfected with BTG2 siRNA, p53 siRNA and siNC and were then examined for the same aforementioned parameters. When treated with a JNK inhibitor of SP600125 and 131I or with a NF-κB inhibitor of BMS-345541 and 131I, non-transfected SW579 cells were assessed in JNK/NFκB pathways. It was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Iodine-131; P53; BTG2; SW579; Thyroid cancer; JNK/NF-κB pathways.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000100608
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lncRNA CCAT1 promotes cell proliferation, migration, and invasion by down-regulation of miR-143 in FTC-133 thyroid carcinoma cell line BJMBR
Yang,Tianzheng; Zhai,Hongyan; Yan,Ruihong; Zhou,Zhenhu; Gao,Lei; Wang,Luqing.
Thyroid cancer is a common malignant tumor. Long non-coding RNA colon cancer-associated transcript 1 (lncRNA CCAT1) is highly expressed in many cancers; however, the molecular mechanism of CCAT1 in thyroid cancer remains unclear. Hence, this study aimed to investigate the effect of CCAT1 on human thyroid cancer cell line FTC-133. FTC-133 cells were transfected with CCAT1 expressing vector, CCAT1 shRNA, miR-143 mimic, and miR-143 inhibitor, respectively. After different treatments, cell viability, proliferation, migration, invasion, and apoptosis were measured. Moreover, the regulatory relationship of CCAT1 and miR-143, as well as miR-143 and VEGF were tested using dual-luciferase reporter assay. The relative expressions of CCAT1, miR-143, and VEGF were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Thyroid cancer; CCAT1; MiR-143; VEGF; PI3K/AKT pathway; MAPK pathway.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000600615
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Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk ArchiMer
Zidane, Monia; Ren, Yen; Xhaard, Constance; Leufroy, Axelle; Côte, Suzanne; Dewailly, Eric; Noël, Laurent; Guérin, Thierry; Bouisset, Patrick; Bernagout, Solène; Paaoafaite, John; Iltis, Jacques; Taquet, Marc; Suhas, Eric; Rachédi, Frédérique; Boissin, Jean Louis; Sebbag, Joseph; Shan, Larrys; Bost-bezeaud, Frédérique; Petitdidier, Patrice; Rubino, Carole; Gardon, Jacques; De Vathaire, Florent.
Background: In French Polynesia, thyroid cancer mortality and incidence is reported to be the highest in the world. Excessive levels of non-essential trace elements (nETE) in the body are associated with several types of cancer. Objective: The present study aims to provide quantitative information on food contamination by mercury (Hg), lead (Pb), arsenic (As) and cadmium (Cd) in French Polynesia and its potential correlation with measurements performed in fingernails of Polynesians, and then to investigate the potential association between these nETE and different thyroid cancer risks. Methods: The study population included 229 interviewed cases and 373 interviewed controls We performed a descriptive analysis of Polynesian food and examined the association...
Tipo: Text Palavras-chave: Thyroid cancer; NETE; Diet; Fingernail; Case-control study.
Ano: 2019 URL: https://archimer.ifremer.fr/doc/00660/77190/78617.pdf
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