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| Registros recuperados: 2.207 | |
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| Soares, Pedro; Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Borges, Fernanda; Queiroz, Maria João R.P.. |
| The development of anticancer drugs inhibiting angiogenesis has been an area of extensive research in the past decade. Angiogenesis is a requirement for tumor growth and metastasis and occurs through several signalling pathways. One key pathway that initiates proliferation and migration of endothelial cells is signalling through the vascular endothelial growth factor receptor-2 (VEGFR-2).1 Therefore, small molecules that block this signalling pathway through inhibition of VEGFR-2 tyrosine kinase activity could potentially inhibit angiogenesis and tumor growth. Recently works describing thienopyrimidine2 and thienopyrimidine 1,3-diarylureas3 as VEGFR-2 inhibitors have emerged in the literature. Here we present the synthesis of new... |
| Tipo: ConferenceObject |
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| Ano: 2011 |
URL: http://hdl.handle.net/10198/6079 |
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| Soares, Pedro; Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Borges, Fernanda; Queiroz, Maria João R.P.. |
| Angiogenesis is a requirement for tumor growth and metastasis and occurs through several signalling pathways. One key pathway that initiates proliferation and migration of endothelial cells is signalling through the vascular endothelial growth factor receptor-2 (VEGFR-2).1 Therefore, small molecules that block this signalling pathway through inhibition of the VEGFR tyrosine kinase activity could potentially inhibit angiogenesis and tumour growth. Recently works describing thienopyrimidines2 and thienopyridine ureas3 as inhibitors of VEGFR-2 have appeared in the literature. Here we present the synthesis of new 1,3-diarylureas 2 starting by regioselective nucleophilic substitution of the 4-chlorothieno[3,2-d]pyrimidine with 4-aminophenol to obtain... |
| Tipo: ConferenceObject |
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| Ano: 2011 |
URL: http://hdl.handle.net/10198/6077 |
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| Santos, Clementina M.M.; Freitas, Marisa; Ribeiro, Daniela; Gomes, Ana; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda. |
| Xanthones are a class of oxygen-containing heterocyclic compounds widely distributed in nature. The natural derivatives can present different substitutions in the xanthone core that include hydroxyl, methoxyl, prenyl and glycosyl groups. The inclusion of aryl groups has only been reported for a few synthetic derivatives, the 2,3-diaryl moiety being recently introduced by our group. Xanthones are endowed with a broad spectrum of biological activities, many of them related to their antioxidant ability, including the scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as metal chelating effects. Considering the interesting and promising antioxidant activities present in compounds derived from the xanthone core, the main... |
| Tipo: Article |
Palavras-chave: 2; 3-Diarylxanthones Reactive oxygen species Reactive nitrogen species Scavenging activity Antioxidant activity. |
| Ano: 2010 |
URL: http://hdl.handle.net/10198/3241 |
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| Fernandes, Eduarda; Carvalho, Félix; Silva, Artur; Santos, Clementina M.M.; Pinto, Diana; Cavaleiro, José; Bastos, Maria de Lourdes. |
| The purpose of this study was the evaluation of the xanthine oxidase (XO) inhibition produced by some synthetic 2-styrylchromones. Ten polyhydroxylated derivatives with several substitution patterns were synthesised, and these and a positive control, allopurinol, were tested for their effects on XO activity by measuring the formation of uric acid from xanthine. The synthesised 2-styrylchromones inhibited xanthine oxidase in a concentration-dependent and non-competitive manner. Some IC50 values found were as low as 0.55mM, which, by comparison with the IC50 found for allopurinol (5.43 mM), indicates promising new inhibitors. Those 2-styrylchromones found to be potent XO inhibitors should be further evaluated as potential agents for the treatment of... |
| Tipo: Article |
Palavras-chave: 2-styrylchromones; Allopurinol; Benzopyrone; Xanthine oxidase inhibition. |
| Ano: 2002 |
URL: http://hdl.handle.net/10198/3931 |
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| Gomes, Ana; Fernandes, Eduarda; Silva, Artur; Pinto, Diana; Santos, Clementina M.M.; Cavaleiro, José; Lima, José Costa. |
| 2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of these compounds has been raised as a matter of interest. Thus the present work consisted in the study of the in vitro scavenging activities for reactive oxygen species (ROS) and reactive nitrogen species (RNS) of various 2-styrylchromone derivatives and structurally similar flavonoids. Some of the studied 2-styrylchromones proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases,... |
| Tipo: Article |
Palavras-chave: 2-Styrylchromones; Reactive oxygen species; Reactive nitrogen species; Scavenging activity; Antioxidant activity. |
| Ano: 2007 |
URL: http://hdl.handle.net/10198/3922 |
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| Martins, Anabela; Santos, M.M.; Santos, Helena; Pais, M.S.. |
| 31 P-Nuclear Magnetic Resonance (NMR) was used to assess phosphate distribution in ectomycorrhizal and nonmycorrhizal roots of Castanea sativa Mill. as well as in the mycorrhizal fungus Pisolithus tinctorius in order to gain insight into phosphate trafficking in these systems. The fungus P. tinctorius accumulated high levels of polyphosphates during the rapid phase of growth. Mycorrhizal and nonmycorrhizal roots accumulate orthophosphate. Only mycorrhizal roots presented polyphosphates. The content in polyphosphates increased along the 3 months of mycorrhiza formation. In mycorrhizal roots of plants cultured under axenic conditions, the orthophosphate pool decreased along the culture time. In nonmycorrhizal roots the decrease in the orthophosphate content... |
| Tipo: Article |
Palavras-chave: Castanea sativa; Pisolithus tinctorius; Ectomycorrhiza; Phosphate; NMR. |
| Ano: 1999 |
URL: http://hdl.handle.net/10198/6420 |
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| Rodrigues, Orlando. |
| Num primeiro ponto, cruzando várias fontes de informação, faz-se uma avaliação genérica dos principais usos do solo na região norte, bem como da sua distribuição geográfica. Depois, numa segunda etapa, tomando a freguesia como unidade geográfica elementar de referência, identificam-se as diversas dinâmicas de relacionamento da sociedade com o território. Para o efeito, recorreu-se a informação sócio-económica secundária(recenseamentos agrícolas e demográficos) conjuntamente com outras fontes de informação sobre a ocupação do solo. Fez-se uma análise do tipo espacial, recorrendo a representações geográficas dos dados, de modo a evidenciar relações com os recursos naturais (em função da diversidade de condições naturais da região) e com as... |
| Tipo: Book |
Palavras-chave: Uso da terra; Região Norte. |
| Ano: 2003 |
URL: http://hdl.handle.net/10198/2723 |
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| Vaz, Madalena; Jorge, Lurdes. |
| Com o objectivo de identificar genes, avaliaram-se nove EST (“Expressed Sequence Tag”) de uma biblioteca de cDNA de Trichoderma harzianum. Numa primeira etapa, as ESTs foram sequenciadas, sendo as sequências analisadas com programas bioinformáticos de análise de similaridade em bancos de dados, utilizando ferramentas como Blast P e Fasta X. Identificaram-se duas ESTs que se enquadravam nos objectivos, sendo uma delas a EST-1279, usada para a completa elucidação do gene lip2 de Trichoderma harzianum, cuja sequência pode ser acedida na base de dados com os códigos de acesso AM774154. O gene lip2 de Trichoderma harzianum sequenciado apresenta 1992 pb, sendo a sua ORF (“open reading frame”) constituída por 1215 nucleótidos. Estão sequenciados 550 pb da região... |
| Tipo: ConferenceObject |
Palavras-chave: Bioinformática; Identificação de genes. |
| Ano: 2011 |
URL: http://hdl.handle.net/10198/5717 |
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| Sousa, Fernando Ruivo de; Fragata, António. |
| A IGP “Carne dos Açores” está inscrita no registo europeu das denominações de origem e indicações geográficas desde 2003 mas não tem ainda presença no mercado. O presente artigo destina-se a contribuir para o esclarecimento das vias de desenvolvimento da indicação geográfica protegida “Carne dos Açores” (IGP). No tratamento da informação recolhida nas nove ilhas da Região Autónoma dos Açores usou-se a análise SWOT, que é um instrumento muito utilizado em “iniciativas de comercialização” para avaliar as principais forças, fraquezas, oportunidades e riscos de um dado produto ou fileira. No artigo é realizado um diagnóstico de situação, baseado nas observações realizadas no terreno e à luz dos conhecimentos actuais sobre a qualidade da carne, são... |
| Tipo: Article |
Palavras-chave: IGP carne dos Açores; Desenvolvimento do mercado. |
| Ano: 2004 |
URL: http://hdl.handle.net/10198/4002 |
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| Costa, José C.; Aguiar, Carlos; Capelo, J.; Lousã, Mário; Castro Antunes, J.H.S.; Honrado, João; Izco, J.; Ladero, M.. |
| Giestais são a designação vulgar em português para as comunidades silicícolas que se inserem na classe Cytisetea scopario-striati e são dominadas por espécies de leguminosas dos géneros Cytisus, Genista, Adenocarpus e Retama. Esta classe tem o seu óptimo na Península Ibérica e representa normalmente as orlas ou etapas de regressão de bosques climácicos da Quercetalia roboris e da Quercion broteroi. No presente trabalho apresentam-se as diversas comunidades da classe Cytisetea scopario-striati que ocorrem em Portugal continental. Propõem-se os seguintes novos sintáxones: Ulici latebracteati-Cytisetum striati cytisetosum grandiflori, Cytiso multiflori-Retametum sphaerocarpae cytisetosum scoparii, Cytiso multiflori-Retametum sphaerocarpae cytisetosum... |
| Tipo: Article |
Palavras-chave: Vegetação de Portugal; Cytisetea scopario-striati. |
| Ano: 2003 |
URL: http://hdl.handle.net/10198/5350 |
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| Vilas-Boas, Miguel; Henderson, M.J.; Freire, C.; Hillman, A.R.; Vieil, E.. |
| The oxidative polymerization of the complex2,3-dimelhyl-N,N-bis( salicylidene)butane-2,3-diaminatonickel( n), [Ni(saltMe)], was monitored by the electrochemical quartz microbalance (EQCM) and crystal impedance techniques. Polymerisation efficiency was maintained throughout deposition of a film, which behaved rigidly, on the electrode. |
| Tipo: Article |
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| Ano: 2000 |
URL: http://hdl.handle.net/10198/5889 |
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| Matos, Alda. |
| (...) quanto essa abençoada arvore se desfaz em beneficios para o homem! Quer dos seus fructos quer da sua madeira, ella distilla perenne riqueza: “pinga” sempre! (...) mas só mais tarde eu conheci que as suas “pingas”, juntas, produziam grossa chuva de oiro na minha província (Magalhães, 1910:184). À semelhança daquela época, actualmente, a comercialização da castanha vem representando uma das principais receitas das explorações agrícolas do Interior Norte de Portugal. O objectivo subjacente a esta comunicação é o de distinguir um dos recursos endógenos vegetais de excepcional importância, sobretudo no Nordeste Transmontano – a castanha – e sua comercialização. Averiguou-se o perfil do agricultor, bem como os aspectos relacionados com a produção, a... |
| Tipo: Other |
Palavras-chave: Castanha portuguesa; Valor comercial; Circuitos; Agentes. |
| Ano: 2006 |
URL: http://hdl.handle.net/10198/932 |
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| Azevedo, João. |
| Changes in landscape pattern caused by changes in forest management, namely the Sustainable Forestry Initiative (SFI), and the implications of these structural changes on landscape processes were analyzed. Landscape structure was studied based upon the comparison of landscapes with different management histories. Ecological processes were analyzed based upon simulation of stand and landscape attributes of habitats for several vertebrate species and upon simulation of hydrological processes such as water and sediment yield. A methodology to integrate landscape and stand pattern and dynamics with landscape processes was developed for this work. It integrates a forest landscape structure model, several stand level growth and yield models, vertebrate habitat... |
| Tipo: DoctoralThesis |
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| Ano: 2003 |
URL: http://hdl.handle.net/10198/2279 |
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| Barbosa, José Carlos; Teixeira, A.; Pereira, F.. |
| This presentation is about milking and working conditions on Serrana goat farms in Trás- os-Montes, a region of northeastern Portugal. The Serrana goat is an indigenous breed and is generally raised to produce milk for cheese-making. Goats are hand-milked inside their shelters. There are no places specifically for milking nor special equipment or facilities to do this work. In collaboration with ANCRAS (Portuguese Serrana breeders' association), we developed a project with the aim of improving milking and working conditions on Serrana goat farms, bearing in mind the socio-economic conditions of breeders. We propose the use of a milking platform with a self-locking barrier in order to improve the posture of milkers and the efficiency of milking.... |
| Tipo: Article |
Palavras-chave: Milking conditions; Working conditions; Goat milking. |
| Ano: 2005 |
URL: http://hdl.handle.net/10198/3160 |
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| Registros recuperados: 2.207 | |
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