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Anti-tumor properties of blackseed (Nigella sativa L.) extracts BJMBR
Ait Mbarek,L.; Ait Mouse,H.; Elabbadi,N.; Bensalah,M.; Gamouh,A.; Aboufatima,R.; Benharref,A.; Chait,A.; Kamal,M.; Dalal,A.; Zyad,A..
The objective of the present study was to evaluate the in vitro and in vivo anti-cancer effect of Nigella sativa L. seed extracts. The essential oil (IC50 = 0.6%, v/v) and ethyl acetate (IC50 = 0.75%) extracts were more cytotoxic against the P815 cell line than the butanol extract (IC50 = 2%). Similar results were obtained with the Vero cell line. Although all extracts had a comparable cytotoxic effect against the ICO1 cell line, with IC50 values ranging from 0.2 to 0.26% (v/v), tests on the BSR cell line revealed a high cytotoxic effect of the ethyl acetate extract (IC50 = 0.2%) compared to the essential oil (IC50 = 1.2%). These data show that the cytotoxicity of each extract depends on the tumor cell type. In vivo, using the DBA2/P815 (H2d) mouse model,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nigella sativa L.; Extracts; Cytotoxicity; Anti-tumor activity.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600014
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Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy BJMBR
Ait M'Barek,L.; Ait Mouse,H.; Jaâfari,A.; Aboufatima,R.; Benharref,A.; Kamal,M; Bénard,J.; El Abbadi,N.; Bensalah,M.; Gamouh,A.; Chait,A.; Dalal,A.; Zyad,A..
The anti-tumor effect of the Moroccan endemic thyme (Thymus broussonettii) essential oil (EOT) was investigated in vitro using the human ovarian adenocarcinoma IGR-OV1 parental cell line OV1/P and its chemoresistant counterparts OV1/adriamycin (OV1/ADR), OV1/vincristine (OV1/VCR), and OV1/cisplatin (OV1/CDDP). All of these cell lines elicited various degrees of sensitivity to the cytotoxic effect of EOT. The IC50 values (mean ± SEM, v/v) were 0.40 ± 0.02, 0.39 ± 0.02, 0.94 ± 0.05, and 0.65 ± 0.03% for OV1/P, OV1/ADR, OV1/VCR, and OV1/CDDP, respectively. Using the DBA-2/P815 (H2d) mouse model, tumors were developed by subcutaneous grafting of tumor fragments of similar size obtained from P815 (murin mastocytoma cell line) injected in donor mouse....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Essential oil; Thymus broussonettii; Ovarian cancer; Cytotoxicity; OV1/adriamycin; OV1/vincristine; OV1/cisplatin.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100014
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