|
|
|
| Registros recuperados: 18 | |
|
|
| Martins,Alex Tadeu; Santos,Fabiano de Sant´Ana dos; Scannavino,Fábio Luiz Ferreira; Pires,Juliana Rico; Zuza,Elizângela Partata; Junior,João Armando Padovani; Azoubel,Reinaldo; Di Mateo,Miguel Angel Sala; Lopes,Ruberval Armando. |
| The cyclamate, a sweetner substance derived from N-cyclo-hexyl-sulfamic acid, is largely utilized as a non-caloric artificial edulcorant in foods and beverages as well as in the pharmaceutical industry. The objective of this study was to evaluate karyometric and stereological alterations in the rat fetal pancreas resulting from the intraperitoneal administration of sodium cyclamate. The exocrine pancreas of ten fetuses of rats were evaluated, five treated and five controls chosen at random, in which five rats that received from the 10th to 14th days of pregnancy an intraperitoneal daily injection of sodium cyclamate at 60 mg/Kg of body weight during 5 days. At the 20th day of gestation, the animals were removed and weighed, as were their placentas; the... |
| Tipo: Journal article |
Palavras-chave: Sodium cyclamate; Exocrine pancreas; Karyometry; Stereology. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300038 |
| |
|
|
| Martins,Alex Tadeu; Azoubel,Reinaldo; Lopes,Ruberval A.; di Matteo,Miguel A. Sala; de Arruda,José Germano Ferraz. |
| The cyclamate, a sweetner substance derived from N-cyclo-hexyl-sulfamic acid, is largely utilized as a non-caloric artificial edulcorant in foods and beverages as well as in the pharmaceutical industry. The objective of this study was to evaluate fetal hepatic karyometric and stereological alterations in the rat fetal liver resulting from the intraperitoneal administration of sodium cyclamate. The livers of ten rats were evaluated, five treated and five controls chosen at random, in which five rats that received from the 10th to 14th days of pregnancy an intraperitoneal daily injection of sodium cyclamate at 60 mg/Kg of body weight during 5 days. At the 20th day of gestation, the animals were removed and weighed, as were their placentas, on a precision... |
| Tipo: Journal article |
Palavras-chave: Sodium cyclamate; Fetal liver; Karyometry; Stereology. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000300005 |
| |
|
|
| Accioly,Marilita Falângola; Souza,Dorotéia Rossi Silva; Padulla,Susimary Aparecida Trevizan; Camargo Filho,José Carlos Silva; do Carmo,Edna Maria; Martins,Alex Tadeu; Brandão,Antônio Carlos; Azoubel,Reinaldo. |
| The present study was carried out to evaluate the effect of statins associated with physical exercise (PE) in liver cells in dyslipidemic rats through cariometry. The animals were divided into six groups: animals subjected to a hypercholesterolemic diet (HD), simvastatin, with (G1) and without (G2) physical exercise (PE); HD submitted (G3) or not (G4) to PE, and commercial food diet (F) with (G5) and without (G6) PE. Histological analysis of the liver was performed by staining the slides with hematoxylin and eosin. The cariometric study included measuring the major and minor diameters of the hepatocytes nuclei. The Shapiro-Wilk test was also performed. To determine the differences among the groups, the Kruskal-Wallis Test with Dunn's post-test were... |
| Tipo: Journal article |
Palavras-chave: Simvastatin; Exercise; Diet; Cariometry. |
| Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000400026 |
| |
|
|
| Alvarez Rosa,Maria José; Dal Pai,Vitalino; Bremer Neto,Hermann; Azoubel,Reinaldo; Nouailhetas,Viviane Louise Andree. |
| We investigated the effect of swimming training in rats on morphological characteristics, hypertrophy levels and metabolic and contractile adaptations of different fiber types in rat the rectus abdominis muscle. Rats were randoverly assigned to one of three groups (N = 5 each): a) swimming training for 1 h, twice a week (2x/w), b) 1 h five times a week (5x/w) for 9 consecutive weeks, or c) without any swimming training (Control). Body weight increased in 2x/w rats and decreased in the 5x/w ones. Muscle fiber diameters increased in both trained groups, with higher values in the 2x/w group. Aerobic exercise increased slow oxidative (SO) + fast-oxidative-glycolytic (FOG) fibers and decreased fast glycolytic (FG) fibers. In addition, SO fibers were increased... |
| Tipo: Journal article |
Palavras-chave: Aerobic exercise; Type fibers; Muscle. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300027 |
| |
|
|
| Martins,Marielza R Ismael; Azoubel,Reinaldo. |
| The objective of this study was the evaluation of aspartame effects on morphometric alterations of the glomerulus, proximal and distal convoluted tubules and collecting ducts of the rat fetal kidney during organogénesis. Fifteen pregnant rats averaging 24 g body weight, were divided into 3 groups (n=5 each) of controls, rats treated with aspartame exposed to room temperature and rats treated with aspartame heated to 40°C. Animals were given 14mg / kg aspartame by the intragastric route on the 9th, 10th, and 11th days of pregnancy. Karyometric and stereological techniques estimated morphological changes. A significant decrease of fetal body weight was observed in the group given aspartame kept at room temperature, compared to controls. Karyometry permitted... |
| Tipo: Journal article |
Palavras-chave: Aspartame; Kidney; Morphometry. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400004 |
| |
|
|
| Pórtela,Gabriela Soares; Azoubel,Reinaldo; Batigália,Fernando. |
| Aspartame is a synthetic sweetener consumed by more than half the adult population in 75 countries. Their metabolites can be toxic, principally to the liver and retina, and there are few studies on the use of aspartame in gestation. Twenty pregnant rats were weighed and allocated randomly (n=5 per group) to receive 14 mg/kg aspartame or water by oral-gastric drip. Treated Tl: aspartame diluted in water at room temperature; Treated T2: aspartame diluted in water heated to 40° C; control Cl: water at room temperature; and control C2: water heated to 40° C. Placentas were weighed, umbilical cords measured and 1000 nuclei of fetal hepatocytes (250 from each group) were analyzed morphometrically utilizing the technique of kariometry, with application of the... |
| Tipo: Journal article |
Palavras-chave: Aspartam; Fetus; Gestation; Liver; Kariometry. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300012 |
| |
|
|
| Leme,Fabíola Azevedo Genovez de Lima; Azoubel,Reinaldo. |
| The present study evaluated the effects of the sweetener aspartame on the fetal pancreas, through a morphometric study, with the objective of studying the exocrine pancreas at the end of gestational development. For this we utilized two treated groups, one with a solution of aspartame at ambient temperature and the other with an aspartame solution heated to 40C, and two groups treated with water ad libitum, at ambient temperature and heated to 40C, respectively. On the final day of gestation the fetuses were removed and the pancreas was collected for microscopic analysis. The morphometric study demonstrated alteration in eight out of the eleven parameters studied in the group treated with the heated solution and one parameter altered in the group treated... |
| Tipo: Journal article |
Palavras-chave: Aspartame; Pancreas; Fetus. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500027 |
| |
|
| |
|
|
| de Matos,Marcelo Alexandre; Martins,Alex Tadeu; Azoubel,Reinaldo. |
| To evaluate the effects of sodium cyclamate on the rat placenta by its administration in the period of embryogenesis. The sodium cyclamate was administered by intraperitoneal route in rats of the treated group at the dose of 60 mg/Kg, from the tenth to fourteenth day of gestation, while the equivalent volume of saline solution was given to the control group, by the same route. On the twentieth day of pregnancy, 10 fetuses (5 from each group) were chosen at random for study. The technique of cariometry was utilized for evaluation of nuclear parameters of cells in deciduous and spongy layers, and of chorionic villi in the rat placenta. The weights of treated fetuses and their placentas were less than those of the control group, while umbilical-cord length in... |
| Tipo: Journal article |
Palavras-chave: Sodium cyclamate; Placenta; Cariometry. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300001 |
| |
|
|
| Padulla,Susimary Aparecida Trevizan; Azoubel,Reinaldo; Bonfim,Mariana Rotta; Accioly,Marilita Falángola; Camargo Filho,José Carlos Silva; Padovani,João Armando; Brandao,Antonio Carlos; Souza,Dorotéia Rossi Silva. |
| Physical exercise and statins, recommended interventions to dyslipidaemia treatment, are independently related to cardiomyocytes alterations, characterized by miocardic hypertrophy and apoptosis, respectively. Thus, the objective of the present study was to analyze the effects of statin and aerobic physical exercise association in the morphometric parameters of cardiac cell nucleus. 40 male rats adults were divided into four groups: exercised (DE); sedentary (DS), exercised and statin use (DES); sedentary and statin use (DSS). The animals received during the whole experimental period a hiperlipidic diet added 20% of coconut oil and 1.25% of cholesterol; after 30 days of its ingestión, a blood collection was made to verify the dyslipidaemia. Simvastatin (20... |
| Tipo: Journal article |
Palavras-chave: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Exercise; Cardiomyocite nuclei. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100015 |
| |
|
|
| Rodero,Ademir B; Batigália,Fernando; Azoubel,Reinaldo; Moura,Arianne Assis; Rodero,Lucas de Souza; Silveira Jr,Landulfo. |
| Sucralose is a sweetener of general use in over three thousand products (beverages, foods and medical diets), with utilization currently permitted for the general population in more than 80 countries, including for women of reproductive age. There is little information on the safe use of sucralose, and experimental studies have suggested that the administration of some sweeteners, by diverse routes, retards not only fetal and placental development but also umbilical cord size. The present study aimed to estimate the fetal and placental weights and umbilical-cord length in fetuses from rat dams, after ingestion and non-ingestion of sucralose. In the treated group (5 dams), sucralose was administered (via gavage) at the dose of 30 mg/kg/day, from the 10th to... |
| Tipo: Journal article |
Palavras-chave: Sucralose; Fetus; Placenta; Umbilical cord; Weight. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300025 |
| |
|
|
| Curi,Viviane; Azoubel,Reinaldo; Lopes,Ruberval Armando; Martins,Alex Tadeu; Sala Di Matteo,Miguel Ángel; Kassis,Elias Naim. |
| The present work studied the adverse effects of maternal exposure of rats to alcohol during lactation, on the development of their off spring. Histometric evaluation by karyometry and of the alveolar bone at the level of the first upper molar of the sucking was perfomed. Two groups of animáis, one coming from mothers exposed to drinking water containing 20% ethanol during the total lactation period and the other of controls coming from mothers receiving only alcohol-free drinking water during this period. On the 21 first day of lactation the young of each group were aleatorily selected and following anesthesia, their heads severed; after histological treatment, serial 6 μm sections on the frontal plañe at the molar level, stained with hematoxilin... |
| Tipo: Journal article |
Palavras-chave: Ethanol; Alveolar bone; Lactation. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000400026 |
| |
|
|
| Kassis,Elias Nairn; Azoubel,Reinaldo; Lopes,Ruberval Armando; Martins,Alex Tadeu; Matteo,Miguel Ángel Sala di; Gawlinski,Viviane Curi. |
| The present work studied the adverse effects of maternal exposure of rats to alcohol during lactation, on the development of their offspring. Histometric evaluation by karyometry and of the palatine epithelium of the sucking was performed. Two groups of animals, one coming from mothers exposed to drinking water containing 20% ethanol during the total lactation period and the other of controls coming from mothers receiving only alcohol-free drinking water during this period. On the 21 first day of lactation the young of each group were aleatorily selected and following anesthesia, their heads severed; after histological treatment, serial 6 |J,m sections on the frontal plane at the molar level, stained with hematoxilin and eosin, were obtained. The... |
| Tipo: Journal article |
Palavras-chave: Ethanol; Palatine epithelium; Lactation. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400013 |
| |
|
|
| Bonfim,Mariana Rotta; Camargo Filho,José Carlos Silva; Vanderlei,Luiz Carlos Marques; Padulla,Susimary Aparecida Trevizan; Accioly,Marilita Falângola; Souza,Dorotéia Rossi Silva; Azoubel,Reinaldo. |
| Physical exercise and statins, which are recommended for the treatment of dyslipidemia, are independently associated to the occurrence of muscle injury. The objective is analyze the effect of aerobic exercise associated to the use of simvastatin on the morphology of the gastrocnemius muscle. Thirty Wistar rats were divided into six groups, two of which received a standard diet (1 sedentary and 1 exercised) and four (1 sedentary with medication, 1 sedentary without medication, 1 exercised with medication, 1 exercised without medication) received a hypercholesterolemic diet (standard diet with the addition of cholesterol and coconut oil). Simvastatin (20 mg/Kg) was administered five days a week for eight weeks, together with aerobic training on a treadmill... |
| Tipo: Journal article |
Palavras-chave: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Exercise; Skeletal Muscle. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400031 |
| |
|
|
| Siéssere,Selma; Semprini,Marisa; Lopes,Ruberval A; Azoubel,Reinaldo; Sala,Miguel A; Mattos,Maria G. C; Hallak Regalo,Simone Cecílio. |
| Phenytoin (diphenylhydantoin, dilantin) has been the chosen anti-convulsive for the treatment of sudden disorders since the late 1930's. Several epidemiological and clinical studies in human beings showed an increase in malformations in descendants of which mothers took phenytoin during gestation, such as cranio-facial development and growth abnormalities, distal phalangeal hypoplasia, and light or moderate mental deficiency. This work had the goal to study the lingual mucosa, under histopathological and morphometric standpoints, in rat fetuses which were given an intraperitonial injection, consisting of a unique dose of phenytoin (70 milligrams/kilogram of their weight). Being that, we included the examined material in paraffin, 6 micrometers thick, and... |
| Tipo: Journal article |
Palavras-chave: Phenytoin; Lingual mucosa; Rat; Morphometry. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200009 |
| |
|
|
| Paschoal,Vánia Del'Arco; Rossit,Andrea Batista; Bizutti,Luiz Onivaldo; Monteiro,Rodrigo; Padovani Junior,Joao Armando; Azoubel,Reinaldo. |
| Ofloxacin presents an ample spectrum of antimicrobial action, including combating Mycobacterium leprae, and is currently employed as a substitute when the use of rifampicin is impossible. The objective of this work was to study alterations in testicular cell nuclei of suckling rats, whose dams were submitted to oral application of ofloxacin, and respective control groups. The method utilized was morphometry by the karyometric technique. The main structures observed in histological preparations of the testicles were interstitial cells, spermatogonias, and sustentacular cells. 10 Wistar rats were utilized, four treated and five controls, in the period of the first 25 days of life, whose dams received ofloxacin 12 mg/ Kg of body weight / day orally, before... |
| Tipo: Journal article |
Palavras-chave: Quinolones; Ofloxacin; Morphology; Karyometry; Nuclear volume; Testicle; Lactation; Sustentacular cells; Rat. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300022 |
| |
|
|
| Rodero,Ademir Barianni; Rodero,Lucas de Souza; Azoubel,Reinaldo. |
| Sucralose is a non-nutritive artificial sweetener, 600 times sweeter than sucrose, and is very stable at high temperatures, among other characteristics. It was approved by the FDA, in 1999, to be utilized in foods, beverages, pharmaceutical products, diets and vitamin supplements. Studies suggest a diffusion, through the placental barrier, of small doses of sucralose and its metabolites. Its hydrolysis products (4-CG e 1,6-DCF) are more rapidly absorbed than sucralose: 4-CG is excreted intact in the urine, and 1,6-DCF undergoes reduction with elimination by the urine or rapid conjugation with glutathione. Various organs can be affected by ingestión of high doses of sucralose. As a result of the rise in global consumption of sweeteners and light- or... |
| Tipo: Journal article |
Palavras-chave: Sucralose; Sweetener; Toxicology. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100040 |
| |
|
|
| Padovani Junior,João Armando; Azoubel,Reinaldo; Martins,Alex Tadeu; Maniglia,José Victor. |
| Laryngeal neoplasms represent 2% of all human cancers. They befall mainly the male sex, especially between 50 and 70 years of age, but exceptionally may occur in infancy or extreme old age. Their occurrence has increased considerably inclusively due to progressive population again. The present work aims at establishing a relation between this infirmity and its prognosis in patients submitted to the treatment recommended by Departament of Otolaryngology and Head Neck Surgery of the School of Medicine of São José do Rio Preto. To this effect, by means of karyometric optical microscopy, cell nuclei in the glottic region of 20 individuals, divided into groups according to their tumor stage and time of survival, were evaluated. Following comparation with a... |
| Tipo: Journal article |
Palavras-chave: Morphometry; Laryngeal neoplasms. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000300015 |
| |
| Registros recuperados: 18 | |
|
|
|
