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Effect of D-alpha-tocopherol on tubular nephron acidification by rats with induced diabetes mellitus BJMBR
Nascimento Gomes,G.; Barbosa,F.T.; Radaeli,R.F.; Cavanal,M.F.; Mello Aires,M.; Zaladek Gil,F..
The objective of the present study was to determine if treatment of diabetic rats with D-alpha-tocopherol could prevent the changes in glomerular and tubular function commonly observed in this disease. Sixty male Wistar rats divided into four groups were studied: control (C), control treated with D-alpha-tocopherol (C + T), diabetic (D), and diabetic treated with D-alpha-tocopherol (D + T). Treatment with D-alpha-tocopherol (40 mg/kg every other day, ip) was started three days after diabetes induction with streptozotocin (60 mg/kg, ip). Renal function studies and microperfusion measurements were performed 30 days after diabetes induction and the kidneys were removed for morphometric analyses. Data are reported as means ± SEM. Glomerular filtration rate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; D-alpha-tocopherol; Renal function; Nephropathy.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700007
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