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Absence of antidiabetic and hypolipidemic effect of Gymnema sylvestre in non-diabetic and alloxan-diabetic rats BABT
Galletto,Ricardo; Siqueira,Vera Lúcia Dias; Ferreira,Edilene Bega; Oliveira,Arildo José Braz; Bazotte,Roberto Barbosa.
In this study we investigated the antidiabetic and hypolipidemic potential of dried powdered leaves of Gymnema sylvestre (GS). The acute effect of GS administered by oral gavage on glucose blood level of and lipids in non-diabetic and alloxan-diabetic rats were investigated in the following conditions: a) after a balanced meal; b) after the ingestion of 1000 mg/kg amylose or 1000 mg/kg glucose; c) after the ingestion of a mixture of 12 mL/kg soybean oil + 1% cholesterol (SOC). In addition, the effect of the treatment with GS during two (sub-acute) or four weeks (chronic) on body weight, food and water ingestion, glucose blood level and lipids in non-diabetic and alloxan-diabetic rats were measured. The dose of GS utilized in the majority of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gymnema sylvestre; Herbal therapies; Diabetes; Asclepideceae.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000400007
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Blood glucose regulation during fasting in rats under food restriction since birth BABT
Vitoriano,Adriana de Souza; Malta,Ananda; Barrena,Helenton Christian; Furlan,Maria Montserrat Diaz Pedrosa; Bazotte,Roberto Barbosa; Gazola,Vilma Godoi.
The effect of severe food restriction since birth on regulation of fasting glycemia in male Wistar rats was investigated. The control group (CG) had free supply of chow, while the restriction group (RG) received 50% of the amount ingested by the CG. The experiments were done in adult (60 days) overnight fasted rats in which glycemia, liver free glucose levels and hepatic glycogen concentration were measured. In part of the experiments in situ liver perfusion was done. The results showed that livers from the RG had higher glycogenolysis rates but lower gluconeogenesis rates from L-alanine (10 mM). Since RG showed maintained glycemia during fasting, it could be concluded that livers from RG produced glucose preferentially from glycogenolysis in detriment of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Food restriction; Rats; Liver; Gluconeogenesis; Glycogenolysis.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000100009
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Comparative effect of glucagon and isoproterenol on hepatic glycogenolysis and glycolysis in isolated perfused liver BABT
Vardanega-Peicher,Márcia; Galletto,Ricardo; Pagliarini e Silva,Sarah; Bazotte,Roberto Barbosa.
The effect of glucagon and isoproterenol (beta-adrenergic agonist) on hepatic glycogenolysis and glycolysis in isolated perfused liver was compared. The levels of isoproterenol and glucagon which promoted the maximal activation of glycogenolysis were 20 muM and 1nM respectively. However, glucagon (1 nM) not only increased glycogenolysis but also inhibited glycolysis. Because adenosine-3'-5'-cyclic monophosphate (cAMP) is a common second messenger to glucagon and isoproterenol, the level of cAMP that simulates the effect of these substances were investigated. The concentration of cAMP that inhibited glycolysis was five times higher (15 muM) than that which stimulated glycogenolysis (3 muM). Similar inhibition of glycolysis was obtained with cAMP agonists...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatic glycolysis; Hepatic glycogenolysis; Glucagon; Isoproterenol; CAMP.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132003000400010
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Comparative performance of lab tests and blood testing device to monitor glucose, total cholesterol and triacylglycerol in type 2 diabetic patients BJPS
Zubioli,Arnaldo; Batista,Marcia Regina; Stefanello,Talitha Fernandes; Carrara,Marcia Aparecida; Bazotte,Roberto Barbosa.
The performance of lab tests (LT) and blood testing devices (BTD) to monitor glycemia vs. glycated hemoglobin A1c (A1c) were compared. In addition, the performance of blood glucose, total cholesterol (TC) and triacylglycerol measured by LT and BDT were compared. All parameters were measured based on the same blood samples from overnight fasted type 2 diabetic patients (T2DP). Linear regression analysis was used for all comparisons. The results showed that A1c correlated better with LT-glucose (r = 0.58) than BTD-glucose (r = 0.42). Moreover, LT vs. BTD showed r values of 0.90, 0.82 and 0.92 for glucose, TC and triacylglycerol, respectively. It was concluded that the performance of LT-glucose was better than BDT-glucose. Moreover, since triacylycerol and TC...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Laboratory tests; Glycated hemoglobin; Glycemia; Total cholesterol; Triacylglycerol; Type 2 diabetes.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300020
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Effects of oral L-carnitine and DL-carnitine supplementation on alloxan-diabetic rats BABT
Bazotte,Roberto Barbosa; Lopes-Bertolini,Gisele.
The effect of oral L-carnitine (LC) or DL-carnitine (DLC) supplementation during one or four weeks (200 or 400 mg.kg-1.day-1) in diabetic rats was investigated. After the supplementation period, the blood was collected for the evaluation of total (TC) and free L-carnitine (FC), glucose, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triacylglycerol. Tissues were collected for the determination of TC and FC concentrations. The carnitine supplementation did not change levels of glucose, total cholesterol, HDL-C and LDL-C in the blood. Diabetic rats showed hypertriacylglycerolemia and decreased blood and tissue levels of FC and TC. Normalization of the blood triacylglycerol and increased blood...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carnitine; Diabetes; Dietary supplementation; Lipids; Rat.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000100010
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Evaluation of the Antidiabetic and Antibacterial Activity of Cissus sicyoides BABT
Beltrame,Flavio Luis; Pessini,Greisiele Lorena; Doro,Dani Luce; Dias Filho,Benedito Prado; Bazotte,Roberto Barbosa; Cortez,Diógenes Aparício Garcia.
In this work we investigated the antidiabetic and antibacterial effect of Cissus sicyoides (CS) from Brazil. Diabetic rats that received water (A group) or extracts from the aerial parts of the plant (Cs group) during four weeks were employed. After this period, serum levels of glucose, cholesterol and triglycerides were measured. Glycemia was not affected by treatment with CS. However, there was an increased cholesterol and triglyceride level in Cs group. In addition, bioassay-guided fractionation of methanolic extract from aerial parts of CS was performed for isolation of antibacterial compounds.beta-Sitosterol and sitosterol-beta-D-glucopyranoside isolated showed antibacterial activity against Bacillus subtilis with minimal inhibitory concentrations...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cissus sicyoides; Vitaceae; Experimental diabetes mellitus; Antibiosis; Steroids.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000100004
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Evaluation of the impact of orally administered carbohydrates on postprandial blood glucose levels in different pre-clinical models BJPS
Marques,Any de Castro Ruiz; Schiavon,Fabiana Percinoto Monteiro; Travassos,Patricia Batista; Eik,Vanessa Fontana; Godoy,Guilherme; Schamber,Christiano Rodrigues; Bazotte,Roberto Barbosa.
ABSTRACT We developed a pre-clinical model in which to evaluate the impact of orally administered carbohydrates on postprandial blood glucose levels. For this purpose, we compared the effects of different carbohydrates with well-established glycemic indexes. We orally administered (gavage) increasing amounts (0.2, 0.4, 0.6, 0.8, and 1.0 g/kg) of sucrose and lactose to rats which had been fasted for 6 h or 15 h, respectively. In part of the experiments we administered frutose (gavagem). Three different models were compared for measuring postprandial blood glucose levels: a) evaluation of interstitial glucose concentrations by using a real time continuous glucose monitoring system; b) evaluation of glucose levels in blood obtained from the rat tail; c)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Glycemic index/study; Glycemic index/oral administration; Glycemic load; Interstitial glucose; Real time continuous glucose monitoring system; Carbohydrates/posprandial glucose levels/rats..
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400761
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Glucose administration inhibits the hepatic activation of gluconeogenesis promoted by insulin-induced hypoglycemia BABT
Galende,Sharize Betoni; Oliveira Neto,Oswaldo Custódio de; Santos,Leandro Freire dos; Peicher,Márcia Vardanega; Souza,Helenir Medri de; Bazotte,Roberto Barbosa.
The activation of hepatic gluconeogenesis in male Wistar adult 6 h fasted rats during insulin-induced hypoglycemia (IIH) was previously demonstrated. In this study, the effects of intraperitoneal (ip) glucose (100 mg/kg) on the activation of liver gluconeogenesis during IIH was investigated. Thus, 6 h fasted rats that received ip regular insulin (1 U/kg) and 30 min later ip saline (Control group) or glucose (Experimental group) were compared. All the experiments were executed 60 min after insulin injection. The glycemia of Control and Experimental groups were not different (P > 0.05). To investigate gluconeogenesis, liver perfusion experiments were performed. The results demonstrated that excepting glycerol, livers from rats which received ip glucose...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypoglycemia; Glycemia recovery; Hepatic metabolism; Gluconeogenesis; Ureagenesis.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000400008
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Glutamine dipeptide supplementation improves clinical responses in patients with diabetic foot syndrome BJPS
Krupek,Tuane; Silva,Maria Angélica Rafaini Covas Pereira da; Sant´Ana,Débora de Mello Gonçalves; Batista,Márcia Regina; Shimauti,Eliana Litsuko Tomimatsu; Sá-Nakanishi,Anacharis Babeto de; Comar,Jurandir Fernando; Schamber,Christiano Rodrigues; Moreschi Junior,Dorival; Bazotte,Roberto Barbosa.
ABSTRACT The effect of glutamine dipeptide (GDP) supplementation in patients with diabetic foot syndrome was evaluated. A total of 22 patients took part in the study. GDP was supplied in 10 g sachets, and was dissolved in water immediately before use, with ingestion once a day, after lunch or after dinner (20 g/day) over a period of 30 days. Quantification of foot insensitive areas, oxidative stress, blood cytokines, and biochemical, hematological and toxicological parameters was performed before and after GDP supplementation. We observed an increase in blood levels of interferon-α (P=0.023), interferon-γ (P=0.038), interleukin-4 (P=0.003), interleukin-6 (P=0.0025), interleukin-7 (P=0.028), interleukin-12 p40 (P=0.017), interleukin-13 (P=0.001), leukocytes...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Type 2 diabetes mellitus/treatment/study; Glutamine/effects; Nutraceuticals..
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300567
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Infliximab treatment prevents hyperglycemia and the intensification of hepatic gluconeogenesis in an animal model of high fat diet-induced liver glucose overproduction BABT
Haida,Karissa Satomi; Bertachini,Gabriela; Tavoni,Thauany; Guilhermetti,Márcio; Loures,Marco Rocha; Bazotte,Roberto Barbosa.
The effect of infliximab on gluconeogenesis in an animal model of diet-induced liver glucose overproduction was investigated. The mice were treated with standard diet (SD group) or high fat diet (HFD group). HFD group were randomly divided and treated either with saline (100 µl/dose, ip, twice a day) or infliximab (10 µg in 100 µl saline per dose, ip, twice a day, i.e., 0.5 mg/kg per day). SD group also received saline. The treatment with infliximab or saline started on the first day of the introduction of the HFD and was maintained during two weeks. After this period, the mice were fasted (15 h) and anesthetized. After laparotomy, blood was collected for glucose determination followed by liver perfusion in which L-alanine (5 mM) was used as gluconeogenic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Infliximab; Hyperglycemia; TNF-alpha; Liver gluconeogenesis; Type 2 diabetes; Mouse.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000300009
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Investigation of risk factors to coronary heart disease in two countryside villages BABT
Silva,Gisleine Elisa Cavalcante da; Bazotte,Roberto Barbosa; Curi,Rui; Silva,Maria Angélica Rafaini Covas Pereira da.
The aim of this study was to investigate risk factors to coronary heart disease in two countryside villages in the State of Paraná, southern Brazil, typical in terms of the poverty and lack of access to public health care. All population was invited to participate in the study. The 462 volunteers (61.3% female, mean age = 42 years) showed high prevalence of hypercholesterolemia (7.0%), hypertriglyceridemia (19.0%), hyperglycemia (11.0%), hypertension (30.0%) and obesity (16.0%). The majority of the individuals, during the interview did not report the diseases detected by the testes. The results revealed that the high prevalence of hypercholesterolemia, hypertriglyceridemia, obesity, hypertension and diabetes mellitus could be consequence of the delayed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hyperlipidemia; Hyperglycemia; Hypertension; Obesity; Coronary heart disease - Paraná State - Brazil.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000300008
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Investigation of the Acute Effects of Dry Extract of Glycine Max on Postprandial Glycemia in Rats BABT
Travassos,Patrícia Batista; Vilela,Vanessa Rodrigues; Antunes,Marina Masetto; Bazotte,Roberto Barbosa.
The acute effects of Glycine max (GM) on post prandial glycemia (PPG) in male Wistar rats were investigated. All substances were orally administered by gavage in overnight fasted animals. The elevation of PPG promoted by starch (1g/kg) was prevented by GM (2.5 mg/kg, 5.0 mg/kg, 7.5 mg/kg, 10.0 mg/kg, and 100.0 mg/kg). In conclusion GM showed potential antidiabetic effect.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Glycine max; Soy; Diabetes; Acarbose; Phytotherapy; Post prandial glycemia.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100316
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Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patients BABT
Silva,Gisleine Elisa Cavalcante da; Assef,Abdol Hakin; Albino,Claudio Cordeiro; Ferri,Letícia de Araujo Funari; Tasin,Gilson; Takahashi,Mirian Hideko; Eik Filho,Wilson; Bazotte,Roberto Barbosa.
The tolerability of stevioside (2.75 mg/kg/day) obtained from leaves of Stevia rebaudiana (Bert) Bertoni (Compositae) was investigated in hyperlipidemic patients. For this purpose a placebo controlled double blind study was performed. The patients were randomized in two groups: the first group received capsules containing placebo and the second group received capsules containing stevioside (50 mg) during 90 days. All capsules were ingested twice daily, i.e., 2 capsules before lunch and 2 capsules before dinner. After the selection of the patients and each 30 days body mass index and laboratory tests (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, total cholesterol, high density lipoprotein, low density lipoprotein, very...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Stevia rebaudiana (Bert) Bertoni; Stevioside; Clinical investigation; Placebo effect.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000500007
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Oral lactate intensifies insulin toxicity during severe insulin-induced hypoglycemia in mice BJPS
Vilela,Vanessa Rodrigues; Antunes,Marina Masetto; Godoi,Vilma Aparecida Ferreira; Travassos,Patricia Batista; Souza,Helenir Medri de; Bazotte,Roberto Barbosa.
ABSTRACT We investigated whether oral lactate could prevent seizures and deaths in mice with severe hypoglycemia induced by a high dose of insulin. For this purpose, mice were fasted for 15 h and then given an intraperitoneal injection of regular insulin (5.0 U/kg or 10.0 U/kg). Immediately after insulin injection, the mice received an oral dose of saline (control), glucose (5.5 mmol/kg), or lactate (18.0 mmol/kg). Glucose and lactate levels were measured in the blood and brain before and after the seizures began. Glucose and lactate delayed (p < 0.05) the onset of seizures associated with severe insulin-induced hypoglycemia. Elevated (p < 0.05) brain levels of lactate were associated with an absence of seizures in mice that received glucose or...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lactatemia; Oral glucose; Diazepam; Seizure; Anticonvulsant effect.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200602
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Oxidative stress parameters as biomarkers of risk factor for diabetic foot among the patients with type 2 diabetes BABT
Oliveira,Ana Carla Pozzi; Teixeira,Caio Jordão; Stefanello,Talitha Fernandes; Carrara,Marcia Aparecida; Bazotte,Roberto Barbosa; Sá-Nakanishi,Anacharis Babeto; Comar,Jurandir Fernando; Batista,Marcia Regina.
The aim of this study was to determine whether plasma levels of carbonylated proteins, total antioxidant capacity (TAC) and reduced protein thiols could be suitable biomarkers of risk factors for diabetic foot. Individuals with type 2 diabetes with normal protective sensation (normal foot group) vs. loss of protective sensation and/or signs of peripheral arterial disease and/or foot deformities and/or history of ulcers and/or neuropathic fractures and/or amputation (diabetic foot group) were compared. The diabetic foot group showed higher carbonylated protein levels (P = 0.0457) and lower levels of TAC (P = 0.0148) and reduced protein thiols (P = 0.0088), compared with the normal foot group. In general, several other parameters of risk of diabetes...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetic foot; Oxidative stress; Total antioxidant capacity; Reduced protein thiols; Protein carbonyls.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000200009
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Pharmaceutical consultation as a tool to improve health outcomes for patients with type 2 diabetes BJPS
Zubioli,Arnaldo; Silva,Maria Angélica Rafaini Covas Pereira da; Tasca,Raquel Soares; Curi,Rui; Bazotte,Roberto Barbosa.
This study develops and evaluates a pharmaceutical consultation program (PCP) to improve treatment for Type 2 diabetes patients (T2DP) and reduce risk factors for diabetic complications with possible application in other chronic diseases. We recruited T2DP receiving conventional medical treatment but with fasting glycemia &gt;140mg/dl and/or glycated hemoglobin &gt;7%. The PCP includes strategies obtained from Dader's method, the PWDT (Pharmacist's Workup of Drug Therapy method) model of pharmaceutical care, the SOAP (Subjective data, Objective data, Assessment, and Plan of care) method, and concepts based on a nursing care model. The PCP evaluated lifestyle, pharmacotherapy and monitoring it using laboratory tests, vital signs, and anthropometry....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pharmaceutical care; Type 2 diabetes/treatment; Type 2 diabetes/pharmaceutical care; Pharmaceutical consultation; Glycated hemoglobin; Diabetes education; Pharmacy.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100010
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Pharmacological studies of Cordia salicifolia Cham in normal and diabetic rats BABT
Siqueira,Vera Lúcia Dias; Cortez,Diógenes Aparicio Garcia; Oliveira,Carlos Eduardo de; Nakamura,Celso Vataru; Bazotte,Roberto Barbosa.
The anti-obesity, appetite suppressant, diuretic and hipolipidemic effect of dried powdered leaves of Cordia salicifolia Cham (CS) were investigated. CS (20 mg.kg-1.day-1) dissolved in water was daily administered by gavage during 13 days. In contrast with the popular use as anti-obesity, appetite suppressant and diuretic, no effect were detected. However, hipolipidemic effect was observed in normal and alloxan-diabetic rats.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Herbal therapies; Hipolipidemic activity; Porangaba; Cordia salicifolia.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000300005
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Response of the lung after pneumonectomy in alloxan diabetic rats BABT
Seidel,Amélia Cristina; Fagundes,Djalma José; Novo,Neil Ferreira; Juliano,Yara; Meister,Hugo; Bazotte,Roberto Barbosa.
In order to determine the response of remaining lung after pneumonectomy during diabetes, female Wistar rats that received an intraperitoneal injection of alloxan (D Group) or saline (C Group) were submitted to lung resection. Six days after alloxan injection (45 mg/kg), diabetes was confirmed. The rats were randomized divided in 3 subgroups: non-operated (NO), sham operation (SO) and left pneumonectomy (PE). Thirty days after the surgery all rats were killed and the weight and volume of the lungs were measured. PE-diabetic rats showed smaller lung weight and volume than PE-non-diabetic animals. The results demonstrated that the compensatory lung growth postpneumonectomy were not observed in diabetic rats.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Experimental diabetes; Alloxan; Pneumonectomy; Lung growth; Rats; Surgery.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132003000200012
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