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| Registros recuperados: 18 | |
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| Zubioli,Arnaldo; Batista,Marcia Regina; Stefanello,Talitha Fernandes; Carrara,Marcia Aparecida; Bazotte,Roberto Barbosa. |
| The performance of lab tests (LT) and blood testing devices (BTD) to monitor glycemia vs. glycated hemoglobin A1c (A1c) were compared. In addition, the performance of blood glucose, total cholesterol (TC) and triacylglycerol measured by LT and BDT were compared. All parameters were measured based on the same blood samples from overnight fasted type 2 diabetic patients (T2DP). Linear regression analysis was used for all comparisons. The results showed that A1c correlated better with LT-glucose (r = 0.58) than BTD-glucose (r = 0.42). Moreover, LT vs. BTD showed r values of 0.90, 0.82 and 0.92 for glucose, TC and triacylglycerol, respectively. It was concluded that the performance of LT-glucose was better than BDT-glucose. Moreover, since triacylycerol and TC... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Laboratory tests; Glycated hemoglobin; Glycemia; Total cholesterol; Triacylglycerol; Type 2 diabetes. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300020 |
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| Beltrame,Flavio Luis; Pessini,Greisiele Lorena; Doro,Dani Luce; Dias Filho,Benedito Prado; Bazotte,Roberto Barbosa; Cortez,Diógenes Aparício Garcia. |
| In this work we investigated the antidiabetic and antibacterial effect of Cissus sicyoides (CS) from Brazil. Diabetic rats that received water (A group) or extracts from the aerial parts of the plant (Cs group) during four weeks were employed. After this period, serum levels of glucose, cholesterol and triglycerides were measured. Glycemia was not affected by treatment with CS. However, there was an increased cholesterol and triglyceride level in Cs group. In addition, bioassay-guided fractionation of methanolic extract from aerial parts of CS was performed for isolation of antibacterial compounds.beta-Sitosterol and sitosterol-beta-D-glucopyranoside isolated showed antibacterial activity against Bacillus subtilis with minimal inhibitory concentrations... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cissus sicyoides; Vitaceae; Experimental diabetes mellitus; Antibiosis; Steroids. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000100004 |
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| Marques,Any de Castro Ruiz; Schiavon,Fabiana Percinoto Monteiro; Travassos,Patricia Batista; Eik,Vanessa Fontana; Godoy,Guilherme; Schamber,Christiano Rodrigues; Bazotte,Roberto Barbosa. |
| ABSTRACT We developed a pre-clinical model in which to evaluate the impact of orally administered carbohydrates on postprandial blood glucose levels. For this purpose, we compared the effects of different carbohydrates with well-established glycemic indexes. We orally administered (gavage) increasing amounts (0.2, 0.4, 0.6, 0.8, and 1.0 g/kg) of sucrose and lactose to rats which had been fasted for 6 h or 15 h, respectively. In part of the experiments we administered frutose (gavagem). Three different models were compared for measuring postprandial blood glucose levels: a) evaluation of interstitial glucose concentrations by using a real time continuous glucose monitoring system; b) evaluation of glucose levels in blood obtained from the rat tail; c)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Glycemic index/study; Glycemic index/oral administration; Glycemic load; Interstitial glucose; Real time continuous glucose monitoring system; Carbohydrates/posprandial glucose levels/rats.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400761 |
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| Galende,Sharize Betoni; Oliveira Neto,Oswaldo Custódio de; Santos,Leandro Freire dos; Peicher,Márcia Vardanega; Souza,Helenir Medri de; Bazotte,Roberto Barbosa. |
| The activation of hepatic gluconeogenesis in male Wistar adult 6 h fasted rats during insulin-induced hypoglycemia (IIH) was previously demonstrated. In this study, the effects of intraperitoneal (ip) glucose (100 mg/kg) on the activation of liver gluconeogenesis during IIH was investigated. Thus, 6 h fasted rats that received ip regular insulin (1 U/kg) and 30 min later ip saline (Control group) or glucose (Experimental group) were compared. All the experiments were executed 60 min after insulin injection. The glycemia of Control and Experimental groups were not different (P > 0.05). To investigate gluconeogenesis, liver perfusion experiments were performed. The results demonstrated that excepting glycerol, livers from rats which received ip glucose... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypoglycemia; Glycemia recovery; Hepatic metabolism; Gluconeogenesis; Ureagenesis. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000400008 |
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| Krupek,Tuane; Silva,Maria Angélica Rafaini Covas Pereira da; Sant´Ana,Débora de Mello Gonçalves; Batista,Márcia Regina; Shimauti,Eliana Litsuko Tomimatsu; Sá-Nakanishi,Anacharis Babeto de; Comar,Jurandir Fernando; Schamber,Christiano Rodrigues; Moreschi Junior,Dorival; Bazotte,Roberto Barbosa. |
| ABSTRACT The effect of glutamine dipeptide (GDP) supplementation in patients with diabetic foot syndrome was evaluated. A total of 22 patients took part in the study. GDP was supplied in 10 g sachets, and was dissolved in water immediately before use, with ingestion once a day, after lunch or after dinner (20 g/day) over a period of 30 days. Quantification of foot insensitive areas, oxidative stress, blood cytokines, and biochemical, hematological and toxicological parameters was performed before and after GDP supplementation. We observed an increase in blood levels of interferon-α (P=0.023), interferon-γ (P=0.038), interleukin-4 (P=0.003), interleukin-6 (P=0.0025), interleukin-7 (P=0.028), interleukin-12 p40 (P=0.017), interleukin-13 (P=0.001), leukocytes... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Type 2 diabetes mellitus/treatment/study; Glutamine/effects; Nutraceuticals.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300567 |
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| Haida,Karissa Satomi; Bertachini,Gabriela; Tavoni,Thauany; Guilhermetti,Márcio; Loures,Marco Rocha; Bazotte,Roberto Barbosa. |
| The effect of infliximab on gluconeogenesis in an animal model of diet-induced liver glucose overproduction was investigated. The mice were treated with standard diet (SD group) or high fat diet (HFD group). HFD group were randomly divided and treated either with saline (100 µl/dose, ip, twice a day) or infliximab (10 µg in 100 µl saline per dose, ip, twice a day, i.e., 0.5 mg/kg per day). SD group also received saline. The treatment with infliximab or saline started on the first day of the introduction of the HFD and was maintained during two weeks. After this period, the mice were fasted (15 h) and anesthetized. After laparotomy, blood was collected for glucose determination followed by liver perfusion in which L-alanine (5 mM) was used as gluconeogenic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Infliximab; Hyperglycemia; TNF-alpha; Liver gluconeogenesis; Type 2 diabetes; Mouse. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000300009 |
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| Silva,Gisleine Elisa Cavalcante da; Bazotte,Roberto Barbosa; Curi,Rui; Silva,Maria Angélica Rafaini Covas Pereira da. |
| The aim of this study was to investigate risk factors to coronary heart disease in two countryside villages in the State of Paraná, southern Brazil, typical in terms of the poverty and lack of access to public health care. All population was invited to participate in the study. The 462 volunteers (61.3% female, mean age = 42 years) showed high prevalence of hypercholesterolemia (7.0%), hypertriglyceridemia (19.0%), hyperglycemia (11.0%), hypertension (30.0%) and obesity (16.0%). The majority of the individuals, during the interview did not report the diseases detected by the testes. The results revealed that the high prevalence of hypercholesterolemia, hypertriglyceridemia, obesity, hypertension and diabetes mellitus could be consequence of the delayed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hyperlipidemia; Hyperglycemia; Hypertension; Obesity; Coronary heart disease - Paraná State - Brazil. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000300008 |
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| Silva,Gisleine Elisa Cavalcante da; Assef,Abdol Hakin; Albino,Claudio Cordeiro; Ferri,Letícia de Araujo Funari; Tasin,Gilson; Takahashi,Mirian Hideko; Eik Filho,Wilson; Bazotte,Roberto Barbosa. |
| The tolerability of stevioside (2.75 mg/kg/day) obtained from leaves of Stevia rebaudiana (Bert) Bertoni (Compositae) was investigated in hyperlipidemic patients. For this purpose a placebo controlled double blind study was performed. The patients were randomized in two groups: the first group received capsules containing placebo and the second group received capsules containing stevioside (50 mg) during 90 days. All capsules were ingested twice daily, i.e., 2 capsules before lunch and 2 capsules before dinner. After the selection of the patients and each 30 days body mass index and laboratory tests (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, total cholesterol, high density lipoprotein, low density lipoprotein, very... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Stevia rebaudiana (Bert) Bertoni; Stevioside; Clinical investigation; Placebo effect. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000500007 |
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| Vilela,Vanessa Rodrigues; Antunes,Marina Masetto; Godoi,Vilma Aparecida Ferreira; Travassos,Patricia Batista; Souza,Helenir Medri de; Bazotte,Roberto Barbosa. |
| ABSTRACT We investigated whether oral lactate could prevent seizures and deaths in mice with severe hypoglycemia induced by a high dose of insulin. For this purpose, mice were fasted for 15 h and then given an intraperitoneal injection of regular insulin (5.0 U/kg or 10.0 U/kg). Immediately after insulin injection, the mice received an oral dose of saline (control), glucose (5.5 mmol/kg), or lactate (18.0 mmol/kg). Glucose and lactate levels were measured in the blood and brain before and after the seizures began. Glucose and lactate delayed (p < 0.05) the onset of seizures associated with severe insulin-induced hypoglycemia. Elevated (p < 0.05) brain levels of lactate were associated with an absence of seizures in mice that received glucose or... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lactatemia; Oral glucose; Diazepam; Seizure; Anticonvulsant effect. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200602 |
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| Oliveira,Ana Carla Pozzi; Teixeira,Caio Jordão; Stefanello,Talitha Fernandes; Carrara,Marcia Aparecida; Bazotte,Roberto Barbosa; Sá-Nakanishi,Anacharis Babeto; Comar,Jurandir Fernando; Batista,Marcia Regina. |
| The aim of this study was to determine whether plasma levels of carbonylated proteins, total antioxidant capacity (TAC) and reduced protein thiols could be suitable biomarkers of risk factors for diabetic foot. Individuals with type 2 diabetes with normal protective sensation (normal foot group) vs. loss of protective sensation and/or signs of peripheral arterial disease and/or foot deformities and/or history of ulcers and/or neuropathic fractures and/or amputation (diabetic foot group) were compared. The diabetic foot group showed higher carbonylated protein levels (P = 0.0457) and lower levels of TAC (P = 0.0148) and reduced protein thiols (P = 0.0088), compared with the normal foot group. In general, several other parameters of risk of diabetes... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diabetic foot; Oxidative stress; Total antioxidant capacity; Reduced protein thiols; Protein carbonyls. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000200009 |
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| Zubioli,Arnaldo; Silva,Maria Angélica Rafaini Covas Pereira da; Tasca,Raquel Soares; Curi,Rui; Bazotte,Roberto Barbosa. |
| This study develops and evaluates a pharmaceutical consultation program (PCP) to improve treatment for Type 2 diabetes patients (T2DP) and reduce risk factors for diabetic complications with possible application in other chronic diseases. We recruited T2DP receiving conventional medical treatment but with fasting glycemia >140mg/dl and/or glycated hemoglobin >7%. The PCP includes strategies obtained from Dader's method, the PWDT (Pharmacist's Workup of Drug Therapy method) model of pharmaceutical care, the SOAP (Subjective data, Objective data, Assessment, and Plan of care) method, and concepts based on a nursing care model. The PCP evaluated lifestyle, pharmacotherapy and monitoring it using laboratory tests, vital signs, and anthropometry.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmaceutical care; Type 2 diabetes/treatment; Type 2 diabetes/pharmaceutical care; Pharmaceutical consultation; Glycated hemoglobin; Diabetes education; Pharmacy. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100010 |
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| Siqueira,Vera Lúcia Dias; Cortez,Diógenes Aparicio Garcia; Oliveira,Carlos Eduardo de; Nakamura,Celso Vataru; Bazotte,Roberto Barbosa. |
| The anti-obesity, appetite suppressant, diuretic and hipolipidemic effect of dried powdered leaves of Cordia salicifolia Cham (CS) were investigated. CS (20 mg.kg-1.day-1) dissolved in water was daily administered by gavage during 13 days. In contrast with the popular use as anti-obesity, appetite suppressant and diuretic, no effect were detected. However, hipolipidemic effect was observed in normal and alloxan-diabetic rats. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Herbal therapies; Hipolipidemic activity; Porangaba; Cordia salicifolia. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000300005 |
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| Registros recuperados: 18 | |
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