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SOUZA, M. M. de; ZERLOTINI NETO, A.; ROCHA, M. I. P.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; CARDOSO, T. F.; CESAR, A. S. M.; AFONSO, J.; ANDRADE, B. G. N.; MUDADU, M. de A.; MOKRY, F. B.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; NICIURA, S. C. M.; COUTINHO, L. L.; REGITANO, L. C. de A.. |
Differences between the expression of the two alleles of a gene are known as allele-specific expression (ASE), a common event in the transcriptome of mammals. Despite ASE being a source of phenotypic variation, its occurrence and effects on genetic prediction of economically relevant traits are still unexplored in bovines. Furthermore, as ASE events are likely driven by cis-regulatory mutations, scanning them throughout the bovine genome represents a significant step to elucidate the mechanisms underlying gene expression regulation. To address this question in a Bos indicus population, we built the ASE profile of the skeletal muscle tissue of 190 Nelore steers, using RNA sequencing data and SNPs genotypes from the Illumina BovineHD BeadChip (770 K bp).... |
Tipo: Artigo em periódico indexado (ALICE) |
Palavras-chave: Expressão gênica; Regulação da expressão gênica; Allelic expression; Allele-specific expression; Bos Indicus; Gene expression regulation. |
Ano: 2020 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1125395 |
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SANTOS, E. C. da S.; PRADIEÉ, J.; GONÇALVES, O. de A.; MADEIRA, E. M.; LAZZARI, J. C.; CARDOSO, T. F.; SCHIAVON, R. S.; PEGORARO, L. M. C.; MONDADORI, R. G.; VIEIRA, A. D.; LUCIA JR, T.. |
2012 |
Tipo: Resumo em anais de congresso (ALICE) |
Palavras-chave: Bovino. |
Ano: 2012 |
URL: http://www.alice.cnptia.embrapa.br/handle/doc/934501 |
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PRADIEÉ, J.; CARDOSO, T. F.; SILVA, E. F.; GONÇALVES, A. O.; GASTAL, G. D. A.; ROSA, C. E.; MONDADORI, R. G.; PEGORARO, L. M. C.; VIEIRA, A. D.; LUCIA JUNIOR, T.. |
2016 |
Tipo: Artigo em periódico indexado (ALICE) |
Palavras-chave: Sheep embryos; Antioxidant; Reactive oxygen species; Frozen ram sperm; Vitrification. |
Ano: 2016 |
URL: http://www.alice.cnptia.embrapa.br/handle/doc/1053502 |
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LIMA, A. O. de; KOLTES, J. E.; DINIZ, W. J. S.; OLIVEIRA, P. S. N. de; CESAR, A. S. M.; TIZIOTO, P. L.; AFONSO, J.; SOUZA, M. de S.; PETRINI, J.; ROCHA, M. I. P.; CARDOSO, T. F.; ZERLOTINI NETO, A.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A.. |
Feed efficiency helps to reduce environmental impacts from livestock production, improving beef cattle profitability. We identified potential biomarkers (hub genes) for feed efficiency, by applying co-expression analysis in Longissimus thoracis RNA-Seq data from 180 Nelore steers. Six co-expression modules were associated with six feed efficiency-related traits (p-value ≤ 0.05). Within these modules, 391 hub genes were enriched for pathways as protein synthesis, muscle growth, and immune response. Trait-associated transcription factors (TFs) ELF1, ELK3, ETS1, FLI1, and TCF4, were identified with binding sites in at least one hub gene. Gene expression of CCDC80, FBLN5, SERPINF1, and OGN was associated with multiple feed efficiency-related traits... |
Tipo: Artigo em periódico indexado (ALICE) |
Palavras-chave: Longissimus thoracis; Biomarcadores; Expressão gênica; Feed efficiency; Hub genes; Systems biology; WGCNA; Bos Indicus; Gene expression. |
Ano: 2020 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1124356 |
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