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Mechanisms and role of microRNA deregulation in cancer onset and progression Genet. Mol. Biol.
Palmero,Edenir Inês; Campos,Silvana Gisele P de; Campos,Marcelo; Souza,Naiara C Nogueira de; Guerreiro,Ismael Dale C.; Carvalho,Andre L.; Marques,Marcia Maria C..
MicroRNAs are key regulators of various fundamental biological processes and, although representing only a small portion of the genome, they regulate a much larger population of target genes. Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20-23 nucleotide (nt) length that control gene expression in many cellular processes. These molecules typically reduce the stability of mRNAs, including those of genes that mediate processes in tumorigenesis, such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis and invasion. MicroRNA targeting is mostly achieved through specific base-pairing interactions between the 5' end ('seed' region) of the miRNA and sites within coding and untranslated regions (UTRs) of mRNAs;...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNA; Cancer; Genetic alteration; Epigenetic alteration; Therapeutic application.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300001
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Physiological and toxic effects of selenium on seed germination of cowpea seedlings Bragantia
Lapaz,Allan de Marcos; Santos,Luiz Felipe de Melo; Yoshida,Camila Hatsu Pereira; Heinrichs,Reges; Campos,Marcelo; Reis,André Rodrigues dos.
ABSTRACT Selenium (Se) is considered a beneficial chemical element for plants, but in high concentrations it may present symptoms of toxicity. The present study aimed to evaluate 11 concentrations of Se (0; 0.1; 0.5; 1; 5; 10; 20; 40; 80; 400; 800 mg.L-1) to determine the low and high (toxicity) critical levels to seed germination of cowpea (Vigna unguiculata). In addition, alterations in the rate of photosynthetic pigments, lipid peroxidation and sugars during the initial growth development of seedlings were analysed. Seeds exposed to 800 mg.L-1 of Se showed a decrease of 20% of seed germination index compared to the control treatment. The decrease in seedling growth reflected in the increase of total sugars and sucrose concentration in both the shoot and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Soluble sugars; Oxidative metabolism; Phytotoxicity; Vigna unguiculata.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0006-87052019000400498
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