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Performance of two-dimensional Doppler echocardiography for the assessment of infarct size and left ventricular function in rats BJMBR
Nozawa,E.; Kanashiro,R.M.; Murad,N.; Carvalho,A.C.C.; Cravo,S.L.D.; Campos,O.; Tucci,P.J.F.; Moises,V.A..
Although echocardiography has been used in rats, few studies have determined its efficacy for estimating myocardial infarct size. Our objective was to estimate the myocardial infarct size, and to evaluate anatomic and functional variables of the left ventricle. Myocardial infarction was produced in 43 female Wistar rats by ligature of the left coronary artery. Echocardiography was performed 5 weeks later to measure left ventricular diameter and transverse area (mean of 3 transverse planes), infarct size (percentage of the arc with infarct on 3 transverse planes), systolic function by the change in fractional area, and diastolic function by mitral inflow parameters. The histologic measurement of myocardial infarction size was similar to the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rats; Myocardial infarction size; Systolic and diastolic function; Doppler echocardiography.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500016
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Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction BJMBR
Saraiva,R.M.; Kanashiro-Takeuchi,R.M.; Antonio,E.L.; Campos,O.; Tucci,P.J.F.; Moisés,V.A..
The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Myocardial infarction; Echocardiography; Hemodynamics.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100016
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