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Registros recuperados: 5
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60Co GAMMA RADIATION EFFECTS ON Apis mellifera VENOM: BIOCHEMICAL, PHARMACOLOGICAL, AND IMMUNOLOGICAL ASPECTS J. Venom. Anim. Toxins
Costa,H..
Tipo: Info:eu-repo/semantics/review
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000100016
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BIOCHEMICAL CHARACTERIZATION OF THE VENOM OF THE SOCIAL WASP Agelaia pallipes pallipes (HYMENOPTERA - VESPIDAE) J. Venom. Anim. Toxins
Costa,H..
Tipo: Info:eu-repo/semantics/other
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301997000100008
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Biodistribution studies of bee venom and spider toxin using radiotracers J. Venom. Anim. Toxins incl. Trop. Dis.
Yonamine,C. M.; Costa,H.; Silva,J. A. A.; Muramoto,E.; Rogero,J. R.; Troncone,L. R. P.; Camillo,M. A. P..
The use of radiotracers allows the understanding of the bioavailability process, biodistribution, and kinetics of any molecule labelled with an isotope, which does not alter the molecule's biological properties. In this work, technetium-99m and iodine-125 were chosen as radiotracers for biodistribution studies in mice using bee (Apis mellifera) venom and a toxin (PnTX2-6) from the Brazilian "armed" spider (Phoneutria nigriventer) venom. Incorporated radioactivity was measured in the blood, brain, heart, lung, liver, kidney, adrenal gland, spleen, stomach, testicle, intestine, muscle, and thyroid gland. Results provided the blood kinetic parameter, and different organs distribution rates.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phoneutria nigriventer; Apis mellifera; Toxin; Venom; Radiotracer; Biodistribution.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000100006
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Effects of 60Co gamma radiation on crotamine BJMBR
Boni-Mitake,M.; Costa,H.; Spencer,P.J.; Vassilieff,V.S.; Rogero,J.R..
Ionizing radiation can change the molecular structure and affect the biological properties of biomolecules. This has been employed to attenuate animal toxins. Crotamine is a strongly basic polypeptide (pI 10.3) from Crotalus durissus terrificus venom composed of 42 amino acid residues. It induces skeletal muscle spasms leading to a spastic paralysis of hind limbs in mice. The objective of the present study was to carry out a biochemical study and a toxic activity assay on native and irradiated crotamine. Crotamine was purified from C.d. terrificus venom by Sephadex G-100 gel filtration followed by ion-exchange chromatography, and irradiated at 2 mg/ml in 0.15 M NaCl with 2.0 kGy gamma radiation emitted by a 60Co source. The native and irradiated toxins...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Crotamine; Gamma radiation; Chromatography; Toxicity; Circular dichroism.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001200004
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PHOSPHOLIPASE A2 FROM HYMENOPTERAN VENOMS:BIOCHEMICAL CHARACTERIZATION J. Venom. Anim. Toxins
Palma,M.S.; Costa,H.; Oliveira,M.R..
Tipo: Info:eu-repo/semantics/other
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301997000200017
Registros recuperados: 5
Primeira ... 1 ... Última
 

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