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Membrane permeabilization of colistin toward pan-drug resistant Gram-negative isolates BJM
Mohamed,Yasmine Fathy; Abou-Shleib,Hamida Moustafa; Khalil,Amal Mohamed; El-Guink,Nadia Mohamed; El-Nakeeb,Moustafa Ahmed.
Abstract Pan-drug resistant Gram-negative bacteria, being resistant to most available antibiotics, represent a huge threat to the medical community. Colistin is considered the last therapeutic option for patients in hospital settings. Thus, we were concerned in this study to demonstrate the membrane permeabilizing activity of colistin focusing on investigating its efficiency toward those pan-drug resistant isolates which represent a critical situation. We determined the killing dynamics of colistin against pan-drug resistant isolates. The permeability alteration was confirmed by different techniques as: leakage, electron microscopy and construction of an artificial membrane model; liposomes. Moreover, selectivity of colistin against microbial cells was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pan-drug resistant; Leakage; Permeability alteration; Colistin; Ultrastructure.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000200381
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