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Inhibitory Effects of Some Flavonoids on Thioredoxin Reductase Purified from Chicken Liver Rev. Bras. Ciênc. Avic.
Türkoğlu,E.A; Kuzu,M; Ayasan,T; Inci,H; Eratak,SV.
ABSTRACT Thioredoxin reductases (TrxRs) are selenocysteine-containing flavoenzymes that reduce Trxin NADPH-dependent manner. In the view of the direct vital role of TrxR in a wide range of biochemical and physiological processes, methods to inhibit this enzyme are clinically important. TrxR has recently emerged as a new candidate in anticancer drug investigations because of overexpression in tumorous cells. In this study, TrxR from chick liver was purified 94.6-fold with a yield of 4.86% and a specific activity of 0.19 EU/mg. KM and Vmax values of TrxR for DTNB were calculated as 0.9 mM and 0,03 EU/mL, respectively. Then, the effects of the flavonoids hesperidin, naringenin, chlorogenic acid, ferulic acid, naringin, 3,4-dihydoxybenzoic acid, and ellagic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Flavonoids; Inhibitors; Natural products; Thioredoxin reductase.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2019000200345
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