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Copy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with the feed conversion ratio in beef cattle. Repositório Alice
SANTANA, M. H. de A.; OLIVEIRA JUNIOR, G. A.; CESAR, A. S. M.; FREUA, M. C.; GOMES, R. da C.; SILVA, S. da L.; LEME, P. R.; FUKUMASU, H.; CARVALHO, M. E.; VENTURA, R. V.; COUTINHO, L. L.; KADARMIDEEN, H. N.; FERRAZ, J. B. S..
The use of genome-wide association results combined with other genomic approaches may uncover genes and metabolic pathways related to complex traits. In this study, the phenotypic and genotypic data of 1475 Nellore (Bos indicus) cattle and 941,033 single nucleotide polymorphisms (SNPs) were used for genome-wide association study (GWAS) and copy number variations (CNVs) analysis in order to identify candidate genes and putative pathways involved with the feed conversion ratio (FCR). The GWAS was based on the Bayes B approach analyzing genomic windows with multiple regression models to estimate the proportion of genetic variance explained by each window. The CNVs were detected with PennCNV software using the log R ratio and B allele frequency data. CNV...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Nellore cattle; GWAS; Cattle; Feed conversion; Genomics; Cucumber necrosis virus; Single nucleotide polymorphism.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1066092
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Molecular characterization of constitutive androstane receptor (CAR) and its association with feed efficiency of Nellore (Bos indicus) cattle. Repositório Alice
ALEXANDRE, P.; SANTANA, M. H. A.; GOMES, R. da C.; FERRAZ, J. B. S.; FUKUMASU, H..
The constitutive androstane receptor (CAR) was initially characterized as a key regulator of xenobiotic metabolism. CAR has also been implicated in various physiological pathways such as energy metabolism and homeostasis of lipids, triglycerides, cholesterol and other endogenous hydrophobic molecules. Here, our focus was to detect genetic polymorphisms (SNP) of CAR of Nellore beef cattle, predict their functional role and associate them to residual feed intake (RFI) and residual body weight gain (RIG), a recently proposed measure of feed efficiency.
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Nutrição animal; Bovino de corte.
Ano: 2012 URL: http://www.alice.cnptia.embrapa.br/handle/doc/952630
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