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DNA repair genes in astrocytoma tumorigenesis, progression and therapy resistance Genet. Mol. Biol.
Sousa,Juliana Ferreira de; Serafim,Rodolfo Bortolozo; Freitas,Laura Marise de; Fontana,Carla Raquel; Valente,Valeria.
Abstract Glioblastoma (GBM) is the most common and malignant type of primary brain tumor, showing rapid development and resistance to therapies. On average, patients survive 14.6 months after diagnosis and less than 5% survive five years or more. Several pieces of evidence have suggested that the DNA damage signaling and repair activities are directly correlated with GBM phenotype and exhibit opposite functions in cancer establishment and progression. The functions of these pathways appear to present a dual role in tumorigenesis and cancer progression. Activation and/or overexpression of ATRX, ATM and RAD51 genes were extensively characterized as barriers for GBM initiation, but paradoxically the exacerbated activity of these genes was further associated...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Glioblastoma; DNA repair; Biomarkers; Tumor progression; Therapy resistance.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200306
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