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	Provedor de dados 48 (2) 52 (1) Autor Guelfi,Marieli (3) Mingatto,Fábio E (2) Bizerra,Paulo F V (1) Maioli,Marcos A (1) Maioli,Marcos Antonio (1) Medeiros,Hyllana C D (1) Medeiros,Hyllana CD (1) Mingatto,Fábio Erminio (1) Moreira,Priscila R (1) Pereira,Flávia TV (1) Santana,Andréia T (1) Tavares,Marco A (1) Tavares,Marco Aurélio (1) Mais... Palavra-chave Bioenergetics (2) Hepatotoxicity (2) Oxidative stress (2) Antioxidant system (1) Biotransformation (1) Bixin (1) Calcium homeostasis (1) Carbon tetrachloride (1) Fertility (1) Fipronil (1) Gossypol (1) Protective activity (1) Vitamin E (1) Mais... Tipo do documento Journal article (2) Info:eu-repo/semantics/article (1) Ano 2015 (2) 2014 (1) País Chile (2) Brazil (1) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Citotoxicity of Fipronil on Hepatocytes Isolated from Rat and Effects of Its Biotransformation 52 Guelfi,Marieli; Maioli,Marcos Antonio; Tavares,Marco Aurélio; Mingatto,Fábio Erminio. ABSTRACT The aim of this study was to characterize the mechanism of toxicity of fipronil on hepatocytes isolated from the rat and the effect of its biotransformation on the toxicological potential. The toxicity of fipronil was assessed by monitoring the oxygen consumption and mitochondrial membrane potential, intracellular ATP concentration, Ca2+ homeostasis and cell viability. The cell viability was evaluated by trypan blue exclusion in hepatocytes that were isolated from the normal rats and by the release of the enzymes alanine transaminase and aspartate transaminase in hepatocytes that were isolated from the normal rats or proadifen-pretreated rats. Fipronil reduced mitochondrial respiration in the cells that were energized with glutamate plus malate in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fipronil; Hepatotoxicity; Bioenergetics; Biotransformation; Calcium homeostasis. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000600843 Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E 48 Santana,Andréia T; Guelfi,Marieli; Medeiros,Hyllana C D; Tavares,Marco A; Bizerra,Paulo F V; Mingatto,Fábio E. BACKGROUND: Gossypol is a chemical present in the seeds of cotton plants (Gossypium sp.) that reduces fertility in farm animals. Vitamin E is an antioxidant and may help to protect cells and tissues against the deleterious effects of free radicals. The aim of this study was to evaluate the mechanisms of reproductive toxicity of gossypol in rats and the protective effects of vitamin E. Forty Wistar rats were used, divided into four experimental groups (n = 10): DMSO/ saline + corn oil; DMSO/saline + vitamin E; gossypol + corn oil; and gossypol + vitamin E. RESULTS: Fertility was significantly reduced in male rats treated with gossypol in that a significant decrease in epididy-mal sperm count was observed (P < 0.05) and the number of offspring was... Tipo: Journal article Palavras-chave: Gossypol; Fertility; Oxidative stress; Bioenergetics; Antioxidant system; Vitamin E. Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100043 Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats 48 Moreira,Priscila R; Maioli,Marcos A; Medeiros,Hyllana CD; Guelfi,Marieli; Pereira,Flávia TV; Mingatto,Fábio E. BACKGROUND: The liver is an important organ for its ability to transform xenobiotics, making the liver tissue a prime target for toxic substances. The carotenoid bixin present in annatto is an antioxidant that can protect cells and tissues against the deleterious effects of free radicals. In this study, we evaluated the protective effect of bixin on liver damage induced by carbon tetrachloride (CCl4) in rats. RESULTS: The animals were divided into four groups with six rats in each group. CCl4 (0.125 mL kg-1 body wt.) was injected intraperitoneally, and bixin (5.0 mg kg-1 body wt.) was given by gavage 7 days before the CCl4 injection. Bixin prevented the liver damage caused by CCl4, as noted by the significant decrease in serum aminotransferases release.... Tipo: Journal article Palavras-chave: Bixin; Carbon tetrachloride; Hepatotoxicity; Oxidative stress; Protective activity. Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100072 Registros recuperados: 3 Primeira ... 1 ... Última

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