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Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammation Biol. Res.
Raju,Golam Sarwar; Moghal,Md Mizanur Rahman; Hossain,Mohammad Salim; Hassan,Md Mahadi; Billah,Md Mustahsan; Ahamed,Sayed Koushik; Rana,SM Masud.
BACKGROUND: The current study aims at evaluating the analgesic, anti-pyretic and anti-inflammatory properties of methanolic extract of the stem, bark and leaves of Launaea sarmentosa and Aegialitis rotundifolia roxb. RESULTS: The AELS and AEAR extract presented a significant (***p < 0.001) dose dependent increase in reaction time in writhing method and showed inhibition of 63.1% and 57.1% respectively at the doses of 400 mg/kg body weight while standard drug showed (P < 0.001) inhibition of 69.23%. In tail immersion method, AELS and AEAR showed maximum time of tail retention at 30 min in hot water i.e. 6.93 sec and 6.54 sec respectively at highest doses of 400 mg/kg body weight than lower dose while standard pentazocine showed reaction time of 7.62...
Tipo: Journal article Palavras-chave: Launaea sarmentosa; Aegialitis rotundifolia roxb; Analgesic; Antipyretic; Anti-inflammatory.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100049
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Development and evaluation of sustained release losartan potassium matrix tablet using kollidon SR as release retardant BJPS
Sarwar,Shahid; Hossain,Mohammad Salim.
The present study was undertaken to develop sustained release (SR) matrix tablets of losartan potassium, an angiotensin-II antagonist for the treatment of hypertension. The tablets were prepared by direct compression method, along with Kollidon SR as release retardant polymer. The amount of losartan potassium remains fixed (100 mg) for all the three formulations whereas the amounts of Kollidon SR were 250 mg, 225 mg, and 200 mg for F-1, F-2, and F-3 respectively. The evaluation involves three stages: the micromeritic properties evaluation of granules, physical property studies of tablets, and in-vitro release kinetics studies. The USP apparatus type II was selected to perform the dissolution test, and the dissolution medium was 900 mL phosphate buffer pH...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Losartan potassium/sustained release; Losartan potassium/development; Losartan potassium/sustained release; Losartan potassium/evaluation; Tablets/direct compression; Kollidon SR./use; Kollidon SR./release retardant.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400005
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