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| Dhillon,Pallavi; Mirza,Mohd. Aamir; Anwer,Md. Khalid; Alshetaili,Abdullah Saud; Alshahrani,Saad Maria; Iqbal,Zeenat. |
| The foremost aim of the current research was to prolong and sustain the release of erythromycin (ERY) by preparing a solid lipid nanoparticles (SLNs)-based gel formulation for the safe and effective treatment of acne. ERY-loaded SLNs were developed, and various process variables were optimized with respect to particle size, zeta potential, and entrapment efficiency using the Taguchi model. The average particle size, PDI, zeta potential, drug entrapment efficiency, and drug loading of optimized SLN (F4) were found to be 176.2±1.82 nm, 0.275±0.011, -34.0±0.84, 73.56%, and 69.74% respectively. The optimized SLN (F4) was successfully incorporated into the carbopol-based hydrogel. The in vitro release of ERY from the SLN gel and plain gel were compared and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Erythromycin; Solid lipid nanoparticles; Nanogel; Taguchi model; Characterization; Diffusion disc. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100583 |
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| Mirza,Mohammad Aamir; Rahman,Mohammad Akhlaquer; Talegaonkar,Sushama; Iqbal,Zeenat. |
| A large majority of new chemical entities and many existing drug molecules exhibit poor aqueous solubility, which may limit their potential use in developing drug formulations, with optimum bioavailability. One of the approaches to improve the solubility of a poorly water soluble drug and eventually its bioavailability is complexation with agents like humic acid (HA), fulvic acid (FA), β-cyclodextrin (β-CD), 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and caffeine (Caff). The current work emphasized at employing these agents to prepare different complexes and their in vitro/in vivo assessment. All the complexes evaluated for their complexation efficiency and authenticated by molecular modeling; conformational analysis, differential scanning calorimetry (DSC),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Itraconazole/complexes; Itraconazole/evaluation; Itraconazole/complexes; Itraconazole/in vitro; Itraconazole/in vivo performance; Vaginal candidiasis/treatment; Drugs/solubility; Drugs/formulation. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400020 |
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