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Flumignan,R.L.G.; Kanashiro,R.M.; Saraiva,R.M.; Portes,L.A.; Antonio,E.L.; Ishigai,M.M.S.; Tucci,P.J.F.. |
The present study reports for the first time the incidence of congestive heart failure (CHF) in previously infarcted rats that died spontaneously. Previously, pulmonary (PWC) and hepatic (HWC) water contents were determined in normal rats: 14 control animals were evaluated immediately after sacrifice, 8 placed in a refrigerator for 24 h, and 10 left at room temperature for 24 h. In the infarcted group, 9 rats died before (acute) and 28 died 48 h after (chronic) myocardial infarction. Thirteen chronic animals were submitted only to autopsy (N = 13), whereas PWC and HWC were also determined in the others (N = 15). Seven rats survived 48 h and died during anesthesia. Notably, PWC differed in normal rats: ambient (75.7 ± 1.3%) < control (77.5 ± 0.7%) <... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Heart failure; Myocardial infarction; Rats; Pulmonary congestion; Hepatic congestion. |
Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001000008 |
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Nozawa,E.; Kanashiro,R.M.; Murad,N.; Carvalho,A.C.C.; Cravo,S.L.D.; Campos,O.; Tucci,P.J.F.; Moises,V.A.. |
Although echocardiography has been used in rats, few studies have determined its efficacy for estimating myocardial infarct size. Our objective was to estimate the myocardial infarct size, and to evaluate anatomic and functional variables of the left ventricle. Myocardial infarction was produced in 43 female Wistar rats by ligature of the left coronary artery. Echocardiography was performed 5 weeks later to measure left ventricular diameter and transverse area (mean of 3 transverse planes), infarct size (percentage of the arc with infarct on 3 transverse planes), systolic function by the change in fractional area, and diastolic function by mitral inflow parameters. The histologic measurement of myocardial infarction size was similar to the... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rats; Myocardial infarction size; Systolic and diastolic function; Doppler echocardiography. |
Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500016 |
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