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Registros recuperados: 3
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CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice BJMBR
Lange,A.P.; Almeida,L.Y.; Araújo Silva,C.L.; Scheucher,P.S.; Chahud,F.; Krause,A.; Bohlander,S.K.; Rego,E.M..
Although rare, CALM/AF10 is a chromosomal rearrangement found in immature T-cell acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia, and mixed phenotype acute leukemia of T/myeloid lineages with poor prognosis. Moreover, this translocation is detected in 50% of T-ALL patients with gamma/delta T cell receptor rearrangement, frequently associated with low expression of transcription factor CCAAT/enhancer-binding protein alpha (CEBPA). However, the relevance of CEBPA low expression for CALM/AF10 leukemogenesis has not yet been evaluated. We generated double mutant mice, which express the Lck-CALM/AF10 fusion gene and are haploinsufficient for the Cebpa gene. To characterize the hematopoiesis, we quantified hematopoietic stem cells, myeloid...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Leukemia; CEBPA; CALM/AF10; Transgenic mice.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000600604
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Sensitization study of dogs with atopic dermatitis in the central region of Rio Grande do Sul Arq. Bras. Med. Vet. Zootec.
Pereira,D.T.; Cunha,V.E.S.; Schmidt,C.; Magnus,T.; Krause,A..
Canine atopic dermatitis (CAD) is a common dermatosis, defined as a genetic-related disease which predisposes to skin inflammation and pruritus, associated to a IgE-specific response in most of cases. Clinical diagnosis may be later complemented by skin allergy and/or serological tests. The aim of these tests is to identify possible allergens in order to enable the clinicians to select candidate antigens for allergen specific immunotherapy. In the present study 58 CAD positive animals were tested. All were submitted to the intradermal test (IDT) and screened for the presence of antibodies against different antigens using ELISA. The obtained results show a high prevalence of sensitization among the tested dogs to house dust mites and to pollen ofC....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Intradermal test; Serological test; House dust mites; Storage mites; Cynodon dactylon.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000601533
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Skin impression with acetate tape in Demodex canis and Scarcoptes scabiei var. vulpes diagnosis Arq. Bras. Med. Vet. Zootec.
Pereira,D.T.; Castro,L.J.M.; Centenaro,V.B.; Amaral,A.S.; Krause,A.; Schmidt,C..
This study compares the efficacy of skin impression with acetate tape and the deep skin scraping test to find D. canis and S. scabieiin dogs. During six months, 134 samples were collected by both techniques from 115 dogs treated at the dermatology service of the Veterinary Hospital of the Federal University of Santa Maria (HVU-UFSM). Of these patients, 27 had demodicosis and 12 had scabies. The impression with acetate tape test (ITT) was shown to be significantly superior to the deep skin scraping test (DSST) in finding D. canis and S. scabiei mites (p = 0.007). Based on our results we could conclude that acetate tape impression is a reliable method for diagnosing and monitoring therapy of dermatopathies caused by mites and can be used to replace the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dog; Acetate tape; Demodicosis; Scabies.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000100049
Registros recuperados: 3
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