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| Bussoni,M.F.; Guirado,G.N.; Roscani,M.G.; Polegato,B.F.; Matsubara,L.S.; Bazan,S.G.Z.; Matsubara,B.B.. |
| Exercise capacity and quality of life (QOL) are important outcome predictors in patients with systolic heart failure (HF), independent of left ventricular (LV) ejection fraction (LVEF). LV diastolic function has been shown to be a better predictor of aerobic exercise capacity in patients with systolic dysfunction and a New York Heart Association (NYHA) classification ≥II. We hypothesized that the currently used index of diastolic function E/e' is associated with exercise capacity and QOL, even in optimally treated HF patients with reduced LVEF. This prospective study included 44 consecutive patients aged 55±11 years (27 men and 17 women), with LVEF<0.50 and NYHA functional class I-III, receiving optimal pharmacological treatment and in a stable clinical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Echocardiography; Left ventricular dysfunction; Six-minute walk test; Dyspnea. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000900803 |
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| Matsubara,B.B.; Franco,M.; Janicki,J.S.; Matsubara,L.S.. |
| It has been recently shown that calcium channel blockers might have a protective effect on cardiac fibrogenesis induced by aldosterone. The objective of this study was to evaluate the protective effect of felodipine, a dihydropyridine calcium channel blocker, against heart and kidney damage caused by aldosterone-high sodium intake in uninephrectomized rats. Wistar rats were divided into three groups: CNEP (uninephrectomized + 1% NaCl in the drinking water, N = 9); ALDO (same as CNEP group plus continuous infusion of 0.75 µg/h aldosterone, N = 12); ALDOF (same as ALDO group plus 30 mg·kg-1·day-1 felodipine in the drinking water, N = 10). All results were compared with those of age-matched, untreated rats (CTL group, N = 10). After 6 weeks, tail cuff blood... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aldosterone; Dihydropyridine; Fibrinoid necrosis; Vascular remodeling; Hypertension; Myocardial remodeling. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500013 |
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| Okoshi,K.; Fioretto,J.R.; Okoshi,M.P.; Cicogna,A.C.; Aragon,F.F.; Matsubara,L.S.; Matsubara,B.B.. |
| Cardiac structures, function, and myocardial contractility are affected by food restriction (FR). There are few experiments associating undernutrition with hypertension. The aim of the present study was to analyze the effects of FR on the cardiac response to hypertension in a genetic model of hypertension, the spontaneously hypertensive rat (SHR). Five-month-old SHR were fed a control or a calorie-restricted diet for 90 days. Global left ventricle (LV) systolic function was evaluated in vivo by transthoracic echocardiogram and myocardial contractility and diastolic function were assessed in vitro in an isovolumetrically beating isolated heart (Langendorff preparation). FR reduced LV systolic function (control (mean ± SD): 58.9 ± 8.2; FR: 50.8 ± 4.8%, N =... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Undernutrition; Isolated heart; Echocardiogram; Langendorff preparation; Ventricular remodeling. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000400019 |
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