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Effect of metabolic acidosis on renal tubular sodium handling in rats as determined by lithium clearance BJMBR
Menegon,L.F.; Figueiredo,J.F.; Gontijo,J.A.R..
Systemic metabolic acidosis is known to cause a decrease in salt and water reabsorption by the kidney. We have used renal lithium clearance to investigate the effect of chronic, NH4Cl-induced metabolic acidosis on the renal handling of Na+ in male Wistar-Hannover rats (200-250 g). Chronic acidosis (pH 7.16 ± 0.13) caused a sustained increase in renal fractional Na+ excretion (267.9 ± 36.4%), accompanied by an increase in fractional proximal (113.3 ± 3.6%) and post-proximal (179.7 ± 20.2%) Na+ and urinary K+ (163.4 ± 5.6%) excretion when compared to control and pair-fed rats. These differences occurred in spite of an unchanged creatinine clearance and Na+ filtered load. A lower final body weight was observed in the acidotic (232 ± 4.6 g) and pair-fed (225 ±...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Renal function; Renal sodium excretion; Lithium clearance; Metabolic acidosis.
Ano: 1998 URL:
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