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| Registros recuperados: 14 | |
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| Souza,D.R.B.; Mill,J.G.; Cabral,A.M.. |
| The present study focused on the role of sympathetic renal nerve activity, in mediating congestive heart failure-induced sodium retention following experimental chronic myocardial infarction. Groups of male Wistar rats (240-260 g) were studied: sham-operated coronary ligation (CON3W, N = 11), coronary ligation and sham-operated renal denervation (INF3W, N = 19), 3 weeks of coronary ligation and sympathetic renal nerve denervation (INF3WDX, N = 6), sham-operated coronary ligation (N = 7), and 16 weeks of coronary ligation (INF16W, N = 7). An acute experimental protocol was used in which the volume overload (VO; 5% of body weight) was applied for 30 min after the equilibration period of continuous iv infusion of saline. Compared to control levels, VO... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Renal denervation; Heart failure; Renal sympathetic nerves; Renal excretory function; Urinary sodium excretion. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000200017 |
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| Carneiro-Júnior,M.A.; Quintão-Júnior,J.F.; Drummond,L.R.; Lavorato,V.N.; Drummond,F.R.; Amadeu,M.A.; Oliveira,E.M.; Felix,L.B.; Cruz,J.S.; Mill,J.G.; Natali,A.J.; Prímola-Gomes,T.N.. |
| In cardiomyocytes, calcium (Ca2+) release units comprise clusters of intracellular Ca2+ release channels located on the sarcoplasmic reticulum, and hypertension is well established as a cause of defects in calcium release unit function. Our objective was to determine whether endurance exercise training could attenuate the deleterious effects of hypertension on calcium release unit components and Ca2+ sparks in left ventricular myocytes of spontaneously hypertensive rats. Male Wistar and spontaneously hypertensive rats (4 months of age) were divided into 4 groups: normotensive (NC) and hypertensive control (HC), and normotensive (NT) and hypertensive trained (HT) animals (7 rats per group). NC and HC rats were submitted to a low-intensity treadmill running... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Physical activity; Hypertension; Cardiomyocyte; Calcium handling; Sarcoplasmic reticulum. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100960 |
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| Dantas,E.M.; Pimentel,E.B.; Gonçalves,C.P.; Lunz,W.; Rodrigues,S.L.; Mill,J.G.. |
| This study evaluated the effects of chronic treadmill training on body mass gain and visceral fat accumulation in overfed rats. Overfeeding was induced by reducing the litter size to 3 male pups per mother during the suckling period. The litter size of control rats was adjusted to 10 male pups per mother. Seven weeks after birth overfed and normally fed rats were selected and assigned to a sedentary protocol or to a low-intensity treadmill training protocol (60 min, 5 times/week, for 9 weeks). Four groups (overfed sedentary, N = 23; normally fed sedentary, N = 32; overfed exercised, N = 18, and normally fed exercised, N = 18) were evaluated at 18 weeks. Data are reported as means ± SEM. Initial body weight was similar in control and overfed rats [8.0 ± 0.2... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Obesity; Exercise; Abdominal fat; Overfeeding. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500014 |
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| Rossoni,L.V.; Amaral,S.M.C.; Vassallo,P.F.; França,A.; Oliveira,E.M.; Varner,K.J.; Mill,J.G.; Vassallo,D.V.. |
| The available data suggests that hypotension caused by Hg2+ administration may be produced by a reduction of cardiac contractility or by cholinergic mechanisms. The hemodynamic effects of an intravenous injection of HgCl2 (5 mg/kg) were studied in anesthetized rats (N = 12) by monitoring left and right ventricular (LV and RV) systolic and diastolic pressures for 120 min. After HgCl2 administration the LV systolic pressure decreased only after 40 min (99 ± 3.3 to 85 ± 8.8 mmHg at 80 min). However, RV systolic pressure increased, initially slowly but faster after 30 min (25 ± 1.8 to 42 ± 1.6 mmHg at 80 min). Both right and left diastolic pressures increased after HgCl2 treatment, suggesting the development of diastolic ventricular dysfunction. Since HgCl2... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mercury; Arterial blood pressure; Ventricular pressure; Pulmonary circulation; Diastolic dysfunction; Cholinergic activity. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800009 |
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| Rocha,W.A.; Lunz,W.; Baldo,M.P.; Pimentel,E.B.; Dantas,E.M.; Rodrigues,S.L.; Mill,J.G.. |
| Angiotensin-converting enzyme inhibitors reduce blood pressure and attenuate cardiac and vascular remodeling in hypertension. However, the kinetics of remodeling after discontinuation of the long-term use of these drugs are unknown. Our objective was to investigate the temporal changes occurring in blood pressure and vascular structure of spontaneously hypertensive rats (SHR). Captopril treatment was started in the pre-hypertensive state. Rats (4 weeks) were assigned to three groups: SHR-Cap (N = 51) treated with captopril (1 g/L) in drinking water from the 4th to the 14th week; SHR-C (N = 48) untreated SHR; Wistar (N = 47) control rats. Subgroups of animals were studied at 2, 4, and 8 weeks after discontinuation of captopril. Direct blood pressure was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: SHR; Cardiac hypertrophy; Aorta remodeling; ACE inhibition; Captopril. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400010 |
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| de Miranda,É.J.F. Peixoto; Hoshi,R.A.; Bittencourt,M.S.; Goulart,A.C.; Santos,I.S.; Brunoni,A.R.; Diniz,M.F.H.S.; Ribeiro,A.L.P.; Dantas,E.M.; Mill,J.G.; Lotufo,P.A.; Benseñor,I.M.. |
| The association between subclinical thyroid dysfunctions and autonomic modulation changes has been described by many studies with conflicting results. We aimed to analyze the association between subclinical hyperthyroidism (SCHyper), subclinical hypothyroidism (SCHypo), and heart rate variability (HRV) using the baseline from ELSA-Brasil. SCHyper and SCHypo were classified by use of medication to treat thyroid disorders, thyrotropin levels respectively above and under the reference range, and normal free thyroxine levels. For HRV, the participants underwent 10 min in supine position and the R-R intervals of the final 5 min were selected for analysis. We first used linear regression models to report crude data and then, multivariate adjustment for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Subclinical hypothyroidism; Subclinical hyperthyroidism; Heart rate variability; Autonomic nervous system. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001100601 |
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| Rodrigues,S.L.; Souza Júnior,P.R.; Pimentel,E.B.; Baldo,M.P.; Malta,D.C.; Mill,J.G.; Szwarcwald,C.L.. |
| High salt intake is related to an increase in blood pressure and development of hypertension. However, currently, there are no national representative data in Brazil using the gold standard method of 24-h urine collection to measure sodium consumption. This study aimed to determine salt intake based on 24-h urine collection in a sample of 272 adults of both genders and to correlate it with blood pressure levels. We used a rigorous protocol to assure an empty bladder prior to initiating urine collection. We excluded subjects with a urine volume <500 mL, collection period outside of an interval of 23-25 h, and subjects with creatinine excretion that was not within the range of 14.4-33.6 mg/kg (men) and 10.8-25.2 mg/kg (women). The mean salt intake was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sodium; Salt intake; Blood pressure; Hypertension; 24-h urine collection; Population-based study. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000800728 |
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| Dantas,E.M.; Gonçalves,C.P.; Silva,A.B.T.; Rodrigues,S.L.; Ramos,M.S.; Andreão,R.V.; Pimentel,E.B.; Lunz,W.; Mill,J.G.. |
| Heart rate variability (HRV) provides important information about cardiac autonomic modulation. Since it is a noninvasive and inexpensive method, HRV has been used to evaluate several parameters of cardiovascular health. However, the internal reproducibility of this method has been challenged in some studies. Our aim was to determine the intra-individual reproducibility of HRV parameters in short-term recordings obtained in supine and orthostatic positions. Electrocardiographic (ECG) recordings were obtained from 30 healthy subjects (20-49 years, 14 men) using a digital apparatus (sampling ratio = 250 Hz). ECG was recorded for 10 min in the supine position and for 10 min in the orthostatic position. The procedure was repeated 2-3 h later. Time and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Heart rate variability; Power spectral analysis; Reproducibility; Autonomic nervous system. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001000010 |
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| Registros recuperados: 14 | |
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